Ethotoin

• 常用名: Ethotoin
• 英文名: Ethotoin
• CAS号: 86-35-1
• 分子量: 204.22500
• 密度: 1.197 g/cm1.197 g/cm3
• 沸点: 342.72°C (rough estimate)
• 分子式: C₁₁H₁₂N₂O₂
• 熔点: 94ºC
• 闪点: N/A

Ethotoin用途

乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。

Ethotoin名称

• 中文名: 乙苯妥英
• 英文名: ethotoin
• 中文别名: 乙基苯妥英

Ethotoin生物活性

• 描述: 乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 在妊娠第18天给药后,乙素(口服灌胃；600 mg/kg；一次)会导致子代的轻微死亡率和体重减轻[2]。动物模型：妊娠Sprague-Dawley CD大鼠[2]剂量：600 mg/kg给药：灌胃；600毫克/千克；一次性结果：伊索酮断奶前死亡率为2.0%,接触伊索酮的动物体重比对照组低约6.6%。
• 参考文献:

  [1]. A S Troupin, et al. Clinical pharmacology of mephenytoin and ethotoin. Ann Neurol. 1979 Nov;6(5):410-4.

  [2]. D R Minck, et al. Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Teratology. 1991 Apr;43(4):279-93.

Ethotoin物理化学性质

• 密度: 1.197 g/cm1.197 g/cm3
• 沸点: 342.72°C (rough estimate)
• 熔点: 94ºC
• 分子式: C₁₁H₁₂N₂O₂
• 分子量: 204.22500
• 精确质量: 204.09000
• PSA: 52.90000
• LogP: 0.87730
• InChIKey: SZQIFWWUIBRPBZ-UHFFFAOYSA-N
• SMILES: CCN1C(=O)NC(c2ccccc2)C1=O
• 折射率: 1.555
• 储存条件: -20°C，密闭，干燥

Ethotoin毒性和生态

Ethotoin安全信息

• 风险声明 (欧洲): 22

Ethotoin靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：Primary high throughput screening by co-culture imaging for identification hits as a ... 来源：23209 靶标：N/A External Id：UIHTS20180925

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

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Ethotoin英文别名

• Etotoina
• Accenon
• Peganone
• Ethotoinum
• 3-Ethyl-5-phenylhydantoin
• 3-Aethyl-5-phenyl-imidazolidin-2,4-dion
• 3-ethyl-5-phenylimidazolidine-2,4-dione
• Pegoanone
• Ethotoine
• 3-ethyl-5-phenyl-imidazolidine-2,4-dione