甘草查尔酮E

• 常用名: 甘草查尔酮E
• 英文名: Licochalcone E
• CAS号: 864232-34-8
• 分子量: 338.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₂O₄
• 熔点: N/A
• 闪点: N/A

甘草查尔酮E用途

Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物,通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。

甘草查尔酮E名称

• 中文名: 甘草查尔酮 E
• 英文名: Licochalcone E

甘草查尔酮E生物活性

• 描述: Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物,通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
• 靶点实验:

  AKT, MAPK, NF-κB[1].

• 参考文献:

  [1]. Lee HN, et al. Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 2013 May 24;14(6):10926-43.

甘草查尔酮E物理化学性质

• 分子式: C₂₁H₂₂O₄
• 分子量: 338.4
• InChIKey: SWPKMTGYQGHLJS-RNVIBTMRSA-N
• SMILES: C=C(C)C(C)c1cc(C=CC(=O)c2ccc(O)cc2)c(OC)cc1O
• 外观性状: 白色结晶粉末
• 储存条件: 2-8°C，密封，干燥

甘草查尔酮E靶点实验

查看更多实验

实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 1... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4035961

实验名称：Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4035959

实验名称：Cytotoxicity in human HepG2 cells expressing Nrf2/ARE-driven luciferase at 10 to 40 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4046719

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4035957

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4035954

实验名称：Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated fo... 来源：ChEMBL 靶标：Polyphenol oxidase 4 External Id：CHEMBL4035963

实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate afte... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL1781409

实验名称：Inhibition of recombinant human PTP1B using pNPP as substrate measured after 30 mins 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4424734

实验名称：Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4035952

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