那拉匹韦

更新时间：2024-01-02 19:51:11

那拉匹韦结构式	常用名	那拉匹韦	英文名	Narlaprevir
	CAS号	865466-24-6	分子量	707.964
	密度	1.2±0.1 g/cm3	沸点	N/A
	分子式	C₃₆H₆₁N₅O₇S	熔点	N/A
	MSDS	N/A	闪点	N/A

那拉匹韦用途

Narlaprevir是口服生物相容性的NS3蛋白酶抑制剂,Ki为6 nM,EC90为40 nM。

中文名	(2S)-2-((4-(((2,7-二甲基-4-氧代-1,4-二氢喹唑啉-6-基)甲基)(丙-2-炔基)氨基)-2-氟苯甲酰)氨基)-4-(1H-四唑-5-基)丁酸
英文名	(1R,2S,5S)-3-[(2S)-2-[[1-(tert-butylsulfonylmethyl)cyclohexyl]carbamoylamino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
英文别名	更多

描述	Narlaprevir是口服生物相容性的NS3蛋白酶抑制剂,Ki为6 nM,EC90为40 nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶信号通路 >> 抗感染 >> HCV 研究领域 >> 感染
参考文献	[1]. Ashok Arasappan, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med. Chem. Lett., 2010, 1 (2), pp 64–69 [2]. Tong X, Arasappan A, Bennett F, Chase R, Feld B, Guo Z, Hart A, Madison V, Malcolm B, Pichardo J, Prongay A, Ralston R, Skelton A, Xia E, Zhang R, Njoroge FG.Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70. Epub 2010 Mar 22. [3]. Zhu J, Li Y, Yu H, Zhang L, Mao X, Hou T.Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses.Comb Chem High Throughput Screen. 2012 Jul;15(6):439-50. [4]. de Bruijne J, Bergmann JF, Reesink HW, Weegink CJ, Molenkamp R, Schinkel J, Tong X, Li J, Treitel MA, Hughes EA, van Lier JJ, van Vliet AA, Janssen HL, de Knegt RJ.Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients.Hepatology. 2010 Nov;52(5):1590-9. [5]. Tomillero A, Moral MA.Gateways to clinical trials.Methods Find Exp Clin Pharmacol. 2010 Nov;32(9):675-703.

描述

Narlaprevir是口服生物相容性的NS3蛋白酶抑制剂,Ki为6 nM,EC90为40 nM。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶

信号通路 >> 抗感染 >> HCV

研究领域 >> 感染

参考文献

[1]. Ashok Arasappan, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med. Chem. Lett., 2010, 1 (2), pp 64–69

[2]. Tong X, Arasappan A, Bennett F, Chase R, Feld B, Guo Z, Hart A, Madison V, Malcolm B, Pichardo J, Prongay A, Ralston R, Skelton A, Xia E, Zhang R, Njoroge FG.Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70. Epub 2010 Mar 22.

[3]. Zhu J, Li Y, Yu H, Zhang L, Mao X, Hou T.Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses.Comb Chem High Throughput Screen. 2012 Jul;15(6):439-50.

[4]. de Bruijne J, Bergmann JF, Reesink HW, Weegink CJ, Molenkamp R, Schinkel J, Tong X, Li J, Treitel MA, Hughes EA, van Lier JJ, van Vliet AA, Janssen HL, de Knegt RJ.Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients.Hepatology. 2010 Nov;52(5):1590-9.

[5]. Tomillero A, Moral MA.Gateways to clinical trials.Methods Find Exp Clin Pharmacol. 2010 Nov;32(9):675-703.

密度	1.2±0.1 g/cm3
分子式	C₃₆H₆₁N₅O₇S
分子量	707.964
精确质量	707.429199
PSA	186.21000
LogP	3.61
折射率	1.558
储存条件	-20°C，密闭，干燥

那拉匹韦上游产品 8
CAS号110-62-3 正戊醛 CAS号4630-82-4 环己甲酸甲酯 CAS号18999-28-5 2-庚烯酸 CAS号40195-26-4 1-甲氧基-1-三甲基甲硅烷基...
CAS号254438-52-3 (2S,3S)-tert-bu... CAS号1184928-27-5 (2S,3S)-3-(benz... CAS号1208245-90-2 (1R,2S,5S)-3-[(... CAS号108-94-1 环己酮
那拉匹韦下游产品 0

(1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

(1R,2S,5S)-N-[(3S)-1-(Cyclopropylamino)-1,2-dioxo-3-heptanyl]-6,6-dimethyl-3-{3-methyl-N-[(1-{[(2-methyl-2-propanyl)sulfonyl]methyl}cyclohexyl)carbamoyl]-L-valyl}-3-azabicyclo[3.1.0]hexane-2-carboxamide

CS-0445

Narlaprevir (USAN/INN)

Narlaprevir

(1R,5S)-N-[1(S)-[2-(cyclopropylamino)-1,2-dioxoethyl]pentyl]-3-[2(S)-[[[[1-[[(1,1-dimethylethyl)sulfonyl]methyl]cyclohexyl]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2(S)-carboxamide

3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-[2-(cyclopropylamino)-1,2-dioxoethyl]pentyl]-3-[(2S)-2-[[[[1-[[(1,1-dimethylethyl)sulfonyl]methyl]cyclohexyl]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-, (1R,2S,5S)-