Pam2CSK4

• 常用名: Pam2CSK4
• 英文名: Pam2CSK4
• CAS号: 868247-72-7
• 分子量: 1271.82
• 密度: 1.1±0.1 g/cm3
• 沸点: 1302.9±65.0 °C at 760 mmHg
• 分子式: C₆₅H₁₂₆N₁₀O₁₂S
• 熔点: N/A
• 闪点: 741.7±34.3 °C

Pam2CSK4用途

Pam2CSK4,一种脂肽,是一种不依赖于 TLR6 的 TLR2 配体和激动剂。Pam2CSK4 促进血小板聚集,并以 TLR2/NF-κB/BTK 依赖性方式增加血小板对胶原蛋白包被表面的粘附。Pam2CSK4 还可激活小鼠巨噬细胞中的 iNOS 表达和 NO 产生。

Pam2CSK4名称

• 英文名: S-[(2R)-2,3-Bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine

Pam2CSK4生物活性

• 描述: Pam2CSK4,一种脂肽,是一种不依赖于 TLR6 的 TLR2 配体和激动剂。Pam2CSK4 促进血小板聚集,并以 TLR2/NF-κB/BTK 依赖性方式增加血小板对胶原蛋白包被表面的粘附。Pam2CSK4 还可激活小鼠巨噬细胞中的 iNOS 表达和 NO 产生。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Parra-Izquierdo I, et al. The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Front Immunol. 2021 Aug 30;12:729951.

  [2]. Kulsantiwong P, et al. Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Inflamm Res. 2017 Oct;66(10):843-853.

  [3]. Kaur A, et al. An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4. RSC Adv. 2018 Mar 5;8(18):9587-9596.

Pam2CSK4物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 1302.9±65.0 °C at 760 mmHg
• 分子式: C₆₅H₁₂₆N₁₀O₁₂S
• 分子量: 1271.82
• 闪点: 741.7±34.3 °C
• 精确质量: 1270.927734
• LogP: 12.33
• InChIKey: LJUIOEFZFQRWJG-GHYFRYPYSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)OCC(CSCC(N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)OC(=O)CCCCCCCCCCCCCCC
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.518

Pam2CSK4靶点实验

查看更多实验

实验名称：Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5105470

实验名称：Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5105471

实验名称：Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant hepatitis B surf... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5105467

实验名称：Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant influenza A/Cali... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5105469

实验名称：Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as inc... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5105462

实验名称：Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha p... 来源：ChEMBL 靶标：Toll-like receptor 6 External Id：CHEMBL5105458

实验名称：Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5105459

实验名称：Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5105460

实验名称：Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as inc... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL5105461

实验名称：Agonist activity at human TLR2 expressed in HEK293 cells assessed as induction of NF-... 来源：ChEMBL 靶标：Toll-like receptor 2 External Id：CHEMBL2184101

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Pam2CSK4英文别名

• S-[(2R)-2,3-Bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine