平板素

• 常用名: 平板素
• 英文名: platencin
• CAS号: 869898-86-2
• 分子量: 425.474
• 密度: 1.4±0.1 g/cm3
• 沸点: 670.1±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₇NO₆
• 熔点: N/A
• 闪点: 359.1±31.5 °C

平板素用途

Platencin是一种从S.platensis分离出来的天然广谱革兰氏阳性抗生素。Platencin抑制β-酮酰基ACP合成酶II和III(分别为FabF和FabH),IC50分别为1.95和3.91μg/ml[1]。

平板素名称

• 中文名: 平板素
• 英文名: Platencin

平板素生物活性

• 描述: Platencin是一种从S.platensis分离出来的天然广谱革兰氏阳性抗生素。Platencin抑制β-酮酰基ACP合成酶II和III(分别为FabF和FabH),IC50分别为1.95和3.91μg/ml[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Wang J, et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6.

平板素物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 670.1±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₇NO₆
• 分子量: 425.474
• 闪点: 359.1±31.5 °C
• 精确质量: 425.183838
• PSA: 127.42000
• LogP: 4.98
• InChIKey: DWUHGPPFFABTIY-KMVHLTCXSA-N
• SMILES: C=C1CC23C=CC(=O)C(C)(CCC(=O)Nc4c(O)ccc(C(=O)O)c4O)C2CC1CC3
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.650
• 储存条件: -20°C，密闭，干燥

平板素靶点实验

查看更多实验

实验名称：Antibacterial activity against Streptococcus pneumoniae at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Streptococcus pneumoniae External Id：CHEMBL1775472

实验名称：Antibacterial activity against Staphylococcus aureus at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1775474

实验名称：Antibacterial activity against Enterococcus faecium at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL1775476

实验名称：Antibacterial activity against Enterococcus faecalis at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL1775475

实验名称：Antibacterial activity against Haemophilus influenzae at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Haemophilus influenzae External Id：CHEMBL1775478

实验名称：Antibacterial activity against Escherichia coli at 64 ug/ml after 20 hrs 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1775477

实验名称：Inhibition of Staphylococcus aureus FAS2 assessed as 2-[14C]malonyl-CoA incorporation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1105339

实验名称：Antibacterial activity against Staphylococcus aureus expressing FabF antisense plasmi... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1105338

实验名称：Antibacterial activity against Staphylococcus aureus Smith after 20 hrs by NCCLS meth... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1105337

实验名称：Antibacterial activity against Staphylococcus aureus Lin after 20 hrs by NCCLS method... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1105336

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平板素英文别名

• platencin
• 2,4-Dihydroxy-3-({3-[(1S,5S,6R)-5-methyl-9-methylene-4-oxotricyclo[6.2.2.0]dodec-2-en-5-yl]propanoyl}amino)benzoic acid