灵芝酮A

• 常用名: 灵芝酮A
• 英文名: Ganoderone A
• CAS号: 873061-79-1
• 分子量: 454.684
• 密度: 1.1±0.1 g/cm3
• 沸点: 568.0±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 熔点: N/A
• 闪点: 311.4±26.6 °C

灵芝酮A用途

Ganoderone A是一种三萜化合物,可从灵芝子实体中分离得到。Ganoderone A对HSV具有抗病毒活性,IC50值为0.3µg/mL。Ganoderone A在病毒感染和肿瘤中具有潜在的应用[1][2][3]。

灵芝酮A名称

• 中文名: 灵芝酮A
• 英文名: Ganoderone A

灵芝酮A生物活性

• 描述: Ganoderone A是一种三萜化合物,可从灵芝子实体中分离得到。Ganoderone A对HSV具有抗病毒活性,IC50值为0.3µg/mL。Ganoderone A在病毒感染和肿瘤中具有潜在的应用[1][2][3]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
• 靶点实验:

  HSV:0.3 μg/mL (IC50)

• 体外研究: 甘露德酮A对 K562、BEL7402和 SGC790型细胞系展现出细胞毒性活性,IC50型值分别为 7.62µM、6.28µM和 3.55µM[3]
• 参考文献:

  [1]. Niedermeyer TH, et al. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod. 2005 Dec;68(12):1728-31.

  [2]. Huang S Z, et al. Anti-allergic prenylated hydroquinones and alkaloids from the fruiting body of Ganoderma calidophilum[J]. RSC advances, 2016, 6(25): 21139-21147.

  [3]. Huang SZ, et al. Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. Phytochemistry. 2017 Nov;143:104-110.

灵芝酮A物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 568.0±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 分子量: 454.684
• 闪点: 311.4±26.6 °C
• 精确质量: 454.344696
• LogP: 6.79
• InChIKey: SDAWCNCFVWQZDP-GOUGDUPLSA-N
• SMILES: CC(=CCCC(C)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(=O)C(C)(C)C1CC3=O)CO
• 外观性状: 白色晶体
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.542
• 储存条件: 2-8°C， 密封， 干燥， 避光

灵芝酮A靶点实验

查看更多实验

实验名称：Antiviral activity against influenza A virus infected in MDCK cells 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL998282

实验名称：Antiviral activity against herpes simplex virus 1 infected in MDCK cells 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL998283

实验名称：Inhibition of Baker's yeast alpha-glucosidase 来源：ChEMBL 靶标：N/A External Id：CHEMBL3594630

实验名称：Inhibition of alpha-glucosidase in rat intestinal mucosa pre-incubated for 40 mins us... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3594631

实验名称：Inhibition of pig liver microsomes HMG-CoA reductase incubated for 5 mins in using HM... 来源：ChEMBL 靶标：3-hydroxy-3-methylglutaryl-coenzyme A reductase External Id：CHEMBL3594629

实验名称：Antimicrobial activity against Candida maltosa SBUG 700 at 200 ug/disk by agar diffus... 来源：ChEMBL 靶标：Candida maltosa External Id：CHEMBL998286

实验名称：Cytotoxicity against human K562 cells by MTT method 来源：ChEMBL 靶标：K562 External Id：CHEMBL3594634

实验名称：Cytotoxicity against human PC3 cells by MTT method 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL3594635

实验名称：Antimicrobial activity against Staphylococcus aureus ATCC 6538 at 200 ug/disk by agar... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL998284

实验名称：Inhibition of sucrase in rat intestinal mucosa pre-incubated for 40 mins using sucros... 来源：ChEMBL 靶标：Sucrase-isomaltase, intestinal External Id：CHEMBL3594632

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灵芝酮A英文别名

• (24E)-26-Hydroxylanosta-8,24-diene-3,7-dione
• GANODERONE A