IWP-2-V2

• 常用名: IWP-2-V2
• 英文名: IWP-2-V2
• CAS号: 877618-79-6
• 分子量: 480.63
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₂₀N₄O₂S₃
• 熔点: N/A
• 闪点: N/A

IWP-2-V2用途

IWP-2-V2 是 IWP-2 (HY-13912) 类似物,保留了对 Wnt/β-catenin 通路的活性。

IWP-2-V2名称

• 中文名: IWP-2-V2
• 英文名: Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-4-oxo-3-(phenylmethyl)thieno[3,2-d]pyrimidin-2-yl]thio]

IWP-2-V2生物活性

• 描述: IWP-2-V2 是 IWP-2 (HY-13912) 类似物,保留了对 Wnt/β-catenin 通路的活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号
• 参考文献:

  [1]. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7. doi: 10.1038/nchembio.

IWP-2-V2物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₃H₂₀N₄O₂S₃
• 分子量: 480.63
• 精确质量: 480.074829
• PSA: 155.72000
• LogP: 5.33
• InChIKey: VBUSMYOJWTVVPF-UHFFFAOYSA-N
• SMILES: Cc1ccc2nc(NC(=O)CSc3nc4c(c(=O)n3Cc3ccccc3)SCC4)sc2c1
• 折射率: 1.770
• 储存条件: -20°C，密闭，干燥

IWP-2-V2靶点实验

查看更多实验

实验名称：Inhibition of porcn in HEK293 cell lysate by Western blot analysis 来源：ChEMBL 靶标：Protein-serine O-palmitoleoyltransferase porcupine External Id：CHEMBL1267180

实验名称：Inhibition of human GST-tagged CK1gamma3 at 10 uM using alpha-casein as substrate aft... 来源：ChEMBL 靶标：Casein kinase I isoform gamma-3 External Id：CHEMBL4189203

实验名称：Inhibition of full-length rat GST-tagged CK1delta at 10 uM using alpha-casein as subs... 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL4189199

实验名称：Inhibition of rat recombinant CK1delta kinase domain at 10 uM using alpha-casein as s... 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL4189200

实验名称：Inhibition of human recombinant CK1epsilon at 10 uM using alpha-casein as substrate a... 来源：ChEMBL 靶标：Casein kinase I isoform epsilon External Id：CHEMBL4189201

实验名称：Inhibition of bovine GST-tagged CK1alpha at 10 uM using alpha-casein as substrate aft... 来源：ChEMBL 靶标：Casein kinase I isoform alpha External Id：CHEMBL4189202

实验名称：Selectivity ratio of IC50 for human CK1epsilon to IC50 for full-length rat GST-tagged... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4189211

实验名称：Selectivity ratio of IC50 for human CK1epsilon to IC50 for rat recombinant CK1delta k... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4189212

实验名称：Ratio of IC50 for full-length rat GST-tagged CK1delta to IC50 for rat recombinant CK1... 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL4189213

实验名称：Selectivity ratio of IC50 for full-length rat GST-tagged CK1delta to IC50 for rat GST... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4189214

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IWP-2-V2英文别名

• 2-[(3-Benzyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide