ML-098

• 常用名: ML-098
• 英文名: ML-098
• CAS号: 878978-76-8
• 分子量: 309.359
• 密度: 1.2±0.1 g/cm3
• 沸点: 535.5±45.0 °C at 760 mmHg
• 分子式: C₁₉H₁₉NO₃
• 熔点: N/A
• 闪点: 277.7±28.7 °C

ML-098用途

ML-098(CID-7345532)是GTP结合蛋白Rab7的激活剂,EC50值为77.6nM。

ML-098名称

• 中文名: ML-098
• 英文名: 1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid

ML-098生物活性

• 描述: ML-098(CID-7345532)是GTP结合蛋白Rab7的激活剂,EC50值为77.6nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
  研究领域 >> 癌症
• 靶点实验:

  EC50: 77.6 nM (Rab7)[1]

• 体外研究: 探针化合物mL098(CID-7345532)通过增加GTP酶对鸟嘌呤核苷酸的亲和力起作用,导致假设这些激活剂与GTP酶相互作用,结合位于开关区I和II之间的变构结合位点。 ML-098是GTP结合蛋白Rab7的活化剂,EC50为77.6 nM,显示出对相关GTP酶cdc42,Ras,Rab-2A和Rac1的选择性(EC50s分别为588.8,346.7,158.5和794.3 nM) )[1]。

ML-098物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 535.5±45.0 °C at 760 mmHg
• 分子式: C₁₉H₁₉NO₃
• 分子量: 309.359
• 闪点: 277.7±28.7 °C
• 精确质量: 309.136505
• PSA: 51.46000
• LogP: 4.96
• InChIKey: LILIWWFBJKBUCO-UHFFFAOYSA-N
• SMILES: Cc1ccc(C)c(OCCn2cc(C(=O)O)c3ccccc32)c1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 2-8℃

ML-098靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Dose response of compounds that promote myeloid differentiation with HOXA9ER cells wi... 来源：NMMLSC External Id：UNMCMD_HOXA9_MYELOIDDIFFERENTIATION_HOXA9ER_SAR01

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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ML-098英文别名

• 1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid
• ML-098