HDS 029

• 常用名: HDS 029
• 英文名: HDS 029
• CAS号: 881001-19-0
• 分子量: 355.75400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₁ClFN₅O
• 熔点: N/A
• 闪点: N/A

HDS 029用途

EGFR/ErbB-2/ErbB-4抑制剂-3(化合物29)是一种有效的酪氨酸激酶抑制剂,对于erbB1、erbB2、erbB4、EGF、HER,其IC50s分别为0.3、1.1、0.5、2.5、24 nM[1]。

HDS 029名称

• 英文名: N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide

HDS 029生物活性

• 描述: EGFR/ErbB-2/ErbB-4抑制剂-3(化合物29)是一种有效的酪氨酸激酶抑制剂,对于erbB1、erbB2、erbB4、EGF、HER,其IC50s分别为0.3、1.1、0.5、2.5、24 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  ErbB2:1.1 nM (IC50)

  ErbB1:0.3 nM (IC50)

  ErbB4:0.5 nM (IC50)

  EGFR:2.5 nM (IC50)

  HER:24 nM (IC50)

• 参考文献:

  [1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85.

HDS 029物理化学性质

• 分子式: C₁₇H₁₁ClFN₅O
• 分子量: 355.75400
• 精确质量: 355.06400
• PSA: 83.29000
• LogP: 4.24520
• InChIKey: DLPSDPPZXRJQOY-UHFFFAOYSA-N
• SMILES: CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1

HDS 029靶点实验

查看更多实验

实验名称：Human erb-b2 receptor tyrosine kinase 4 (Type I RTKs: ErbB (epidermal growth factor) ... 来源：IUPHAR-DB 靶标：erb-b2 receptor tyrosine kinase 4 (Type I RTKs: ErbB (epidermal growth factor) receptor family) [Homo sapiens] External Id：1799_Human

实验名称：Human erb-b2 receptor tyrosine kinase 2 (Type I RTKs: ErbB (epidermal growth factor) ... 来源：IUPHAR-DB 靶标：erb-b2 receptor tyrosine kinase 2 (Type I RTKs: ErbB (epidermal growth factor) receptor family) [Homo sapiens] External Id：2019_Human

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

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HDS 029英文别名

• HMS3229E05
• EGFR/ErbB-2/ErbB-4 Inhibitor
• IN1346
• HDS 029