iMDK

• 常用名: iMDK
• 英文名: iMDK
• CAS号: 881970-80-5
• 分子量: 376.404
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₁H₁₃FN₂O₂S
• 熔点: N/A
• 闪点: N/A

iMDK用途

iMDK是生长因子Midkine(MDK)的小分子抑制剂,可抑制MDK的内源性表达,但不抑制其他生长因子如PTN或VEGF；抑制含有致癌KRAS突变的MDK阳性H441肺腺癌细胞的细胞生长和H520鳞状细胞肺癌细胞,抑制PI3K途径并诱导细胞凋亡；显着抑制体内异种移植小鼠模型中的肿瘤生长。

iMDK名称

• 英文名: 3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one

iMDK生物活性

• 描述: iMDK是生长因子Midkine(MDK)的小分子抑制剂,可抑制MDK的内源性表达,但不抑制其他生长因子如PTN或VEGF；抑制含有致癌KRAS突变的MDK阳性H441肺腺癌细胞的细胞生长和H520鳞状细胞肺癌细胞,抑制PI3K途径并诱导细胞凋亡；显着抑制体内异种移植小鼠模型中的肿瘤生长。
• 参考文献: References 1. Hao H, et al. PLoS One. 2013 Aug 16;8(8):e71093. 2. Ishida N, et al. Exp Cell Res. 2015 Jul 15;335(2):197-206. 3. Masui M, et al. Anticancer Res. 2016 Jun;36(6):2775-81. View Related Products by Target Midkine

iMDK物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₁H₁₃FN₂O₂S
• 分子量: 376.404
• 精确质量: 376.068176
• LogP: 6.14
• InChIKey: IWFKQTWYILKFGE-UHFFFAOYSA-N
• SMILES: O=c1oc2ccccc2cc1-c1cn2cc(Cc3ccc(F)cc3)sc2n1
• 折射率: 1.711
• 储存条件: -20°C，干燥，密封

iMDK安全信息

• 危害码 (欧洲): Xi

iMDK靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：A screen for compounds that inhibit cell wall-associated teichoic acid synthesis in S... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS704

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

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iMDK英文别名

• 3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
• MFCD07528492