iMDK
Modify Date: 2024-01-09 10:44:46
iMDK structure
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Common Name | iMDK | ||
|---|---|---|---|---|
| CAS Number | 881970-80-5 | Molecular Weight | 376.404 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H13FN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of iMDKiMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF; inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis; significantly inhibits tumor growth in a xenograft mouse model in vivo. |
| Name | 3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one |
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| Synonym | More Synonyms |
| Description | iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF; inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis; significantly inhibits tumor growth in a xenograft mouse model in vivo. |
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| References | References 1. Hao H, et al. PLoS One. 2013 Aug 16;8(8):e71093. 2. Ishida N, et al. Exp Cell Res. 2015 Jul 15;335(2):197-206. 3. Masui M, et al. Anticancer Res. 2016 Jun;36(6):2775-81. View Related Products by Target Midkine |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H13FN2O2S |
| Molecular Weight | 376.404 |
| Exact Mass | 376.068176 |
| LogP | 6.14 |
| Index of Refraction | 1.711 |
| Hazard Codes | Xi |
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| 3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one |
| 2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]- |
| MFCD07528492 |