JP104

• 常用名: JP104
• 英文名: JP104
• CAS号: 887264-45-1
• 分子量: 410.549
• 密度: 1.1±0.1 g/cm3
• 沸点: 565.9±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄N₂O₃
• 熔点: N/A
• 闪点: 296.0±30.1 °C

JP104用途

JP104 是一种氨基甲酸芳基酯,是一种不可逆的 FAAH 抑制剂,pIC50 约为 8。

JP104名称

• 中文名: JP104
• 英文名: 3'-Carbamoyl-3-biphenylyl undecylcarbamate

JP104生物活性

• 描述: JP104 是一种氨基甲酸芳基酯,是一种不可逆的 FAAH 抑制剂,pIC50 约为 8。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> FAAH
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> FAAH
• 靶点实验:

  pIC50: ~8 (FAAH)[1]

• 参考文献:

  [1]. Catherine Michaux, et al. Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4772-6.

JP104物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 565.9±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄N₂O₃
• 分子量: 410.549
• 闪点: 296.0±30.1 °C
• 精确质量: 410.256958
• PSA: 85.90000
• LogP: 6.76
• InChIKey: BCKBOXGAYIOHDQ-UHFFFAOYSA-N
• SMILES: C#CCCCCCCCCCNC(=O)Oc1cccc(-c2cccc(C(N)=O)c2)c1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.541
• 储存条件: -20°C，密闭，干燥

JP104靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：Invivo inhibition of rhodamine-azide tagged FAAH expressed in mouse brain at 10 mg/kg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5654272

实验名称：Invivo inhibition of rhodamine-azide tagged FAAH expressed in mouse liver at 10 mg/kg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5654273

实验名称：In vivo inhibition of rhodamine-azide tagged FAAH in FAAH knockout mouse liver at 10 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5654274

实验名称：Ex vivo inhibition of EST31 in C57BL/6 mouse liver at 1 mg/kg, ip after 1 hr relative... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3101737

实验名称：Ex vivo inhibition of EST31 in C57BL/6 mouse kidney at 1 mg/kg, ip after 1 hr relativ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3101738

实验名称：Ex vivo inhibition of CE6 in C57BL/6 mouse liver at 1 mg/kg, ip after 1 hr relative t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3101739

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JP104英文别名

• 3'-Carbamoyl-3-biphenylyl undecylcarbamate
• Carbamic acid, N-undecyl-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester