PH-064

• 常用名: PH-064
• 英文名: PH-064
• CAS号: 892546-37-1
• 分子量: 795.11400
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₄H₅₈N₈O₂S₂
• 熔点: N/A
• 闪点: N/A

PH-064用途

PH-064 (BIM-46187) 是摘自专利FR 2879460 A1中的钠离子通道抑制剂。

PH-064名称

• 中文名: PH-064
• 英文名: (2R,2'R)-3,3'-Disulfanediylbis{2-amino-1-[(8S)-8-(cyclohexylmethy l)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-1-propanon e}

PH-064生物活性

• 描述: PH-064 (BIM-46187) 是摘自专利FR 2879460 A1中的钠离子通道抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Pain-relieving compositions containing a dihydroimidazopyrazine derivative. From Fr. Demande (2006), FR 2879460 A1 20060623.

PH-064物理化学性质

• 分子式: C₄₄H₅₈N₈O₂S₂
• 分子量: 795.11400
• 精确质量: 794.41200
• PSA: 178.90000
• LogP: 9.13360
• InChIKey: GGDNOAWICIHSAW-KEAHXZLPSA-N
• SMILES: NC(CSSCC(N)C(=O)N1CCn2cc(-c3ccccc3)nc2C1CC1CCCCC1)C(=O)N1CCn2cc(-c3ccccc3)nc2C1CC1CCCCC1
• 储存条件: 2-8℃

PH-064靶点实验

查看更多实验

实验名称：Antiproliferative activity against human MP41 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352549

实验名称：Inhibition of colony formation in human MP41 cells assessed as inhibition of cell pro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352566

实验名称：Antiproliferative activity against human 921 cells assessed as reduction in cell viab... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352550

实验名称：Antiproliferative activity against human MP41 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352563

实验名称：Inhibition of Galphaq/11 (unknown origin) expressed in CHO-M1 cells at 10 uM preincub... 来源：ChEMBL 靶标：Guanine nucleotide-binding protein G(q) subunit alpha External Id：CHEMBL5352548

实验名称：Antiproliferative activity against human 921 cells assessed as reduction in cell viab... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352564

实验名称：Antiproliferative activity against human A-375 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：A-375 External Id：CHEMBL5352559

实验名称：Antiproliferative activity against human SK-MEL-2 cells assessed as reduction in cell... 来源：ChEMBL 靶标：SK-MEL-2 External Id：CHEMBL5352560

实验名称：Inhibition of cell migration in human MP41 cells at 1 uM incubated for 24 hrs by woun... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352569

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PH-064英文别名

• PH-064