咪瑞司他

• 常用名: 咪瑞司他
• 英文名: IMIRESTAT
• CAS号: 89391-50-4
• 分子量: 286.23300
• 密度: 1.58g/cm3
• 沸点: N/A
• 分子式: C₁₅H₈F₂N₂O₂
• 熔点: N/A
• 闪点: N/A

咪瑞司他用途

IMIRESTAT 是一种 aldose reductase 抑制剂，可用于治疗糖尿病。

咪瑞司他名称

• 中文名: 咪瑞司他
• 英文名: 2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione

咪瑞司他生物活性

• 描述: Imirestat (AL 1576) 是一种 aldose reductase 抑制剂,可用于治疗糖尿病。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 醛糖还原酶
  研究领域 >> 代谢疾病
• 体内研究: Imirestat(1 mg/kg)可改善神经传导速度,但不会影响对缺氧传导阻滞的抵抗或胰岛素刺激的对人体敏感的ATP酶活性的缺陷[1]。
• 参考文献:

  [1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401.

咪瑞司他物理化学性质

• 密度: 1.58g/cm3
• 分子式: C₁₅H₈F₂N₂O₂
• 分子量: 286.23300
• 精确质量: 286.05500
• PSA: 58.20000
• LogP: 2.68580
• InChIKey: QCCHBHSAIQIQGO-UHFFFAOYSA-N
• SMILES: O=C1NC(=O)C2(N1)c1cc(F)ccc1-c1ccc(F)cc12
• 折射率: 1.692
• 储存条件: 2-8℃

咪瑞司他毒性和生态

咪瑞司他靶点实验

查看更多实验

实验名称：In vivo inhibition of SCoR2 in ischemia/reperfusion induced acute kidney injury mouse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340500

实验名称：Protection against ischemia/reperfusion induced acute kidney injury in mouse assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5340501

实验名称：Protection against ischemia/reperfusion induced acute kidney injury in mouse assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5340498

实验名称：Protection against ischemia/reperfusion induced acute kidney injury in mouse assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5340499

实验名称：Selectivity as ratio of IC50 for rat lens and kidney aldose reductase 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1 External Id：CHEMBL851664

实验名称：In vivo inhibition of SCoR2 in mouse assessed as reduction in SNO-CoA metabolic activ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340496

实验名称：In vivo inhibition of SCoR2 in ischemia/reperfusion induced acute kidney injury mouse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340497

实验名称：Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Esch... 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member A1 External Id：CHEMBL5340495

实验名称：Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichi... 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1 External Id：CHEMBL5340493

实验名称：Selectivity index, ratio of IC50 for inhibition of human recombinant AKR1B1 expressed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340491

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咪瑞司他英文别名

• Imirestatum [INN-Latin]
• Alcon 1576
• 2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione
• 2,7-di-fluoro-spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione
• Imirestat
• spiro-[2,7-difluorofluoren-9,4'-imidazolidine]-2',5'-dione
• Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,2,7-difluoro
• [14C]-Imirestat
• Spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione
• HOE 843