IMIRESTAT

Modify Date: 2025-08-25 16:03:00

IMIRESTAT Structure
IMIRESTAT structure
Common Name IMIRESTAT
CAS Number 89391-50-4 Molecular Weight 286.23300
Density 1.58g/cm3 Boiling Point N/A
Molecular Formula C15H8F2N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IMIRESTAT


Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

 Names

Name 2,7-difluorospiro[fluorene-9,5'-imidazolidine]-2',4'-dione
Synonym More Synonyms

 IMIRESTAT Biological Activity

Description Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
Related Catalog
In Vivo Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity[1].
References

[1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401.

 Chemical & Physical Properties

Density 1.58g/cm3
Molecular Formula C15H8F2N2O2
Molecular Weight 286.23300
Exact Mass 286.05500
PSA 58.20000
LogP 2.68580
Index of Refraction 1.692
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1307300
CHEMICAL NAME :
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-
CAS REGISTRY NUMBER :
89391-50-4
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H8-F2-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg/14D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
700 mg/kg/14D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),137,1997

 Synthetic Route

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IMIRESTAT Structure

IMIRESTAT

CAS#:89391-50-4

Literature: Alcon Laboratories, Inc. Patent: US4436745 A1, 1984 ; Title/Abstract Full Text Show Details Alcon Laboratories, Inc. Patent: US4540700 A1, 1985 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Imirestatum [INN-Latin]
Alcon 1576
2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione
2,7-di-fluoro-spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione
Imirestat
spiro-[2,7-difluorofluoren-9,4'-imidazolidine]-2',5'-dione
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,2,7-difluoro
[14C]-Imirestat
Spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione
HOE 843
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