InhA-IN-4

• 常用名: InhA-IN-4
• 英文名: InhA-IN-4
• CAS号: 894309-72-9
• 分子量: 366.23
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₂BrN₃O₂S
• 熔点: N/A
• 闪点: N/A

InhA-IN-4用途

InhA-IN-4(TU14)是一种结核分枝杆菌InhA(烯醇ACP还原酶)抑制剂,IC50为15.6μM[1]。

InhA-IN-4名称

• 英文名: InhA-IN-4

InhA-IN-4生物活性

• 描述: InhA-IN-4(TU14)是一种结核分枝杆菌InhA(烯醇ACP还原酶)抑制剂,IC50为15.6μM[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 15.6 μM (InhA)[1]

• 体外研究: InhA-IN-4(TU14)显示抗结核活性,对结核分枝杆菌的MIC为1.56±0.82µg/mL[1]。
• 参考文献:

  [1]. Doğan ŞD, et al. Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors. Eur J Med Chem. 2020 Aug 1;199:112402.

InhA-IN-4物理化学性质

• 分子式: C₁₄H₁₂BrN₃O₂S
• 分子量: 366.23

InhA-IN-4靶点实验

查看更多实验

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhib... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4770216

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4770217

实验名称：Inhibition of recombinant Mycobacterium tuberculosis His6-tagged InHA expressed in Es... 来源：ChEMBL 靶标：Enoyl-[acyl-carrier-protein] reductase [NADH] External Id：CHEMBL4770220

实验名称：Inhibition of recombinant Mycobacterium tuberculosis His6-tagged InHA expressed in Es... 来源：ChEMBL 靶标：Enoyl-[acyl-carrier-protein] reductase [NADH] External Id：CHEMBL4770221

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