4-[[6-[(6-甲基磺酰基-2-甲基吡啶-3-基)氨基]-5-甲氧基嘧啶-4-基]氧基]哌啶-1-羧酸异丙酯

• 常用名: 4-[[6-[(6-甲基磺酰基-2-甲基吡啶-3-基)氨基]-5-甲氧基嘧啶-4-基]氧基]哌啶-1-羧酸异丙酯
• 英文名: JNJ-38431055
• CAS号: 897732-93-3
• 分子量: 479.550
• 密度: 1.3±0.1 g/cm3
• 沸点: 648.3±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₉N₅O₆S
• 熔点: N/A
• 闪点: 345.9±31.5 °C

用途

APD597是GPR119激动剂, 作用于hGPR119, EC50为46 nM, 可用于治疗2型糖尿病。

名称

• 中文名: 4-[[6-[(6-甲基磺酰基-2-甲基吡啶-3-基)氨基]-5-甲氧基嘧啶-4-基]氧基]哌啶-1-羧酸异丙酯
• 英文名: propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate

生物活性

• 描述: APD597是GPR119激动剂, 作用于hGPR119, EC50为46 nM, 可用于治疗2型糖尿病。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335.

  [2]. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755.

  [3]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 648.3±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₉N₅O₆S
• 分子量: 479.550
• 闪点: 345.9±31.5 °C
• 精确质量: 479.183868
• PSA: 141.22000
• LogP: 2.90
• InChIKey: WPDCHTSXOPUOII-UHFFFAOYSA-N
• SMILES: COc1c(Nc2ccc(S(C)(=O)=O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.570
• 储存条件: -20℃

靶点实验

查看更多实验

实验名称：Intrinsic activity at human GPR119 receptor assessed as cAMP production by HTRF assay... 来源：ChEMBL 靶标：Glucose-dependent insulinotropic receptor External Id：CHEMBL1953651

实验名称：Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay 来源：ChEMBL 靶标：Glucose-dependent insulinotropic receptor External Id：CHEMBL1953650

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Intrinsic activity at rat GPR119 receptor assessed as cAMP production by HTRF assay r... 来源：ChEMBL 靶标：Glucose-dependent insulinotropic receptor External Id：CHEMBL1953652

实验名称：Solubility in 20% HPbetaCD after 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL1953654

实验名称：Antidiabetic activity in fasted C57bl/6j mouse assessed as reduction in AUC of glucos... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1953657

实验名称：Thermal Shift Assay. Domain: start/stop: M1-S360 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL5067150

实验名称：Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay 来源：ChEMBL 靶标：Glucose-dependent insulinotropic receptor External Id：CHEMBL1953649

实验名称：AUC (0 to infinity) in C57Bl mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1953669

实验名称：AUC (0 to infinity) in Beagle dog at 7.85 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1953671

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英文别名

• adp-597
• Isopropyl 4-[(5-methoxy-6-{[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino}-4-pyrimidinyl)oxy]-1-piperidinecarboxylate
• 1-Piperidinecarboxylic acid, 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-, 1-methylethyl ester
• JNJ-38431055
• APD597