TP-10

• 常用名: TP-10
• 英文名: TP-10
• CAS号: 898563-00-3
• 分子量: 460.45000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₁₉F₃N₄O
• 熔点: N/A
• 闪点: N/A

TP-10用途

TP-10是PDE10A 抑制剂, IC50 为0.8 nM。

TP-10名称

• 中文名: 2-{4-[4-吡啶-4-基-1-(2,2,2-三氟-乙基)-1H-吡唑-3-基]-苯氧基甲基}-喹啉
• 英文名: 2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline

TP-10生物活性

• 描述: TP-10是PDE10A 抑制剂, IC50 为0.8 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213.

  [2]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem

TP-10物理化学性质

• 分子式: C₂₆H₁₉F₃N₄O
• 分子量: 460.45000
• 精确质量: 460.15100
• PSA: 52.83000
• LogP: 6.30160
• InChIKey: NOIXNOMHHWGUTG-UHFFFAOYSA-N
• SMILES: FC(F)(F)Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1
• 储存条件: 2-8℃

TP-10靶点实验

查看更多实验

实验名称：Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleot... 来源：ChEMBL 靶标：cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A External Id：CHEMBL3369961

实验名称：Selectivity ratio of IC50 for recombinant PDE1A to IC50 for recombinant PDE10A 来源：ChEMBL 靶标：N/A External Id：CHEMBL2187861

实验名称：Selectivity ratio of IC50 for recombinant PDE1C to IC50 for recombinant PDE10A 来源：ChEMBL 靶标：N/A External Id：CHEMBL2187859

实验名称：Selectivity ratio of IC50 for recombinant PDE1B to IC50 for recombinant PDE10A 来源：ChEMBL 靶标：N/A External Id：CHEMBL2187860

实验名称：Inhibition of rat recombinant PDE10A transfected in Sf9 cells 来源：ChEMBL 靶标：cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A External Id：CHEMBL1051662

实验名称：Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubat... 来源：ChEMBL 靶标：cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A External Id：CHEMBL1960211

实验名称：Lipophilicity, log D of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1827313

实验名称：Selectivity ratio of IC50 for rat PDE10A to IC50 for rat PDE3A 来源：ChEMBL 靶标：N/A External Id：CHEMBL1827312

实验名称：Selectivity ratio of IC50 for rat PDE10A to IC50 for rat PDE3B 来源：ChEMBL 靶标：N/A External Id：CHEMBL1827315

实验名称：PDE Enzyme Inhibition Assay from Article 10.1021/jm900521k: "Discovery of a Novel Cla... 来源：BindingDB 靶标：N/A External Id：BindingDB_3342_1

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TP-10英文别名

• TP-10