CPUY074020

• 常用名: CPUY074020
• 英文名: CPUY074020
• CAS号: 902279-44-1
• 分子量: 416.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₈N₄O₂
• 熔点: N/A
• 闪点: N/A

CPUY074020用途

CPUY074020 是一种有效的 G9a 抑制剂,IC50 值为 2.18 μM,具有抗增殖活性。

CPUY074020名称

• 英文名: CPUY074020

CPUY074020生物活性

• 描述: CPUY074020 是一种有效的 G9a 抑制剂,IC50 值为 2.18 μM,具有抗增殖活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
• 靶点实验:

  IC50: 2.18 μM (G9a)[1]

• 参考文献:

  [1]. Chen WL, et al. Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular. Bioorg Med Chem. 2016 Nov 15;24(22):6102-6108.

CPUY074020物理化学性质

• 分子式: C₂₅H₂₈N₄O₂
• 分子量: 416.52
• InChIKey: MMSYVEFXRAMWBA-UHFFFAOYSA-N
• SMILES: O=C1c2ccccc2-c2onc3c(N4CCCCC4)cc(NCCN4CCCC4)c1c23
• 储存条件: 2-8°C，密封，干燥

CPUY074020靶点实验

查看更多实验

实验名称：Volume of distribution in Sprague-Dawley rat at 10 mg/kg, iv after 2 mins to 24 hrs b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859835

实验名称：Half life in Sprague-Dawley rat at 10 mg/kg, iv after 2 mins to 24 hrs by LC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859831

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, iv after 2 mins to 24 hrs by LC-MS/MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859832

实验名称：Clearance in Sprague-Dawley rat at 10 mg/kg, iv after 2 mins to 24 hrs by LC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3859834

实验名称：Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 8 uM after 4... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3859819

实验名称：Induction of apoptosis in human MCF7 cells assessed as viable cells at 8 uM after 48 ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3859820

实验名称：Inhibition of G9a in human MCF7 cells assessed as decrease in dimethylation level of ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3859821

实验名称：Inhibition of G9a in human MCF7 cells assessed as decrease in trimethylation level of... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3859822

实验名称：Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 4 uM after 4... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3859815

实验名称：Induction of apoptosis in human MCF7 cells assessed as viable cells at 4 uM after 48 ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3859816

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CPUY074020英文别名

• MFCD14777686