UBP310

• 常用名: UBP310
• 英文名: UBP 310
• CAS号: 902464-46-4
• 分子量: 353.35000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₅N₃O₆S
• 熔点: N/A
• 闪点: N/A

UBP310用途

UBP310是一种选择性GluR5拮抗剂,其Kd为130 nM[1]。

UBP310名称

• 英文名: 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)

UBP310生物活性

• 描述: UBP310是一种选择性GluR5拮抗剂,其Kd为130 nM[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点实验:

  GluR5[1]

• 体外研究: UBP310以130 nM的亲和力与GluR5 S1S2结合,显示出GluR5对GluR6的12700倍选择性和GluR5对GluR2的830倍选择性[1]。
• 参考文献:

  [1]. Mark L Mayer, et al. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J Neurosci. 2006 Mar 15;26(11):2852-61.

UBP310物理化学性质

• 分子式: C₁₄H₁₅N₃O₆S
• 分子量: 353.35000
• 精确质量: 353.06800
• PSA: 172.86000
• LogP: 0.23860
• InChIKey: ZTAZUCRXCRXNSU-VIFPVBQESA-N
• SMILES: Cc1cn(CC(N)C(=O)O)c(=O)n(Cc2ccsc2C(=O)O)c1=O
• 储存条件: -20°C，密闭，干燥

UBP310靶点实验

查看更多实验

实验名称：Agonist activity at rat GluK2 mutant expressed in Xenopus oocytes at 1 mM by two-elec... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1817062

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Ratio of Ki for rat GluA2 to Ki for rat GluK1 来源：ChEMBL 靶标：N/A External Id：CHEMBL1817067

实验名称：Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cells 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 3 External Id：CHEMBL1817066

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Ratio of Ki for rat GluK3 to Ki for rat GluK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1817068

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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