α类固醇脱氢酶

更新时间：2025-08-25 22:50:38

α类固醇脱氢酶结构式	常用名	α类固醇脱氢酶	英文名	3alpha-hydroxysteroid dehydrogenase
	CAS号	9028-56-2	分子量	N/A
	密度	N/A	沸点	N/A
	分子式	N/A	熔点	N/A
	MSDS	美版	闪点	N/A

α类固醇脱氢酶用途

3α-羟基类固醇脱氢酶(3α-HSD)是一种由AKR1C4基因编码的酶,可以催化3-酮甾体转化为3α-羟化合物。3α-羟基类固醇脱氢酶在雄激素DHT的失活中起着重要作用,可将DHT转化为雄激素活性较弱的3α-雄甾二醇,可用于多毛症的研究[1]。

中文名	类固醇脱氢酶
英文名	Dehydrogenase 3alpha-hydroxy steroid
中文别名	羟基甾族化合物氧化还原酶 \| 羥固醇 \| 3Α-羟基类固醇脱氢酶 \| 类固醇脱氢酶 \| 3Α羟基类固醇脱氢酶/羟基甾族化合物氧化还原酶/羟固醇/HSD
英文别名	更多

描述	3α-羟基类固醇脱氢酶(3α-HSD)是一种由AKR1C4基因编码的酶,可以催化3-酮甾体转化为3α-羟化合物。3α-羟基类固醇脱氢酶在雄激素DHT的失活中起着重要作用,可将DHT转化为雄激素活性较弱的3α-雄甾二醇,可用于多毛症的研究[1]。
相关类别	研究领域 >> 内分泌
参考文献	[1]. Anne Z Steiner, et al. 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr;93(4):1298-303.

InChIKey	WZWONBSCKCYGIW-UHFFFAOYSA-N
SMILES	O=C1C(=O)c2ccccc2C1=Cc1cc2c(s1)C1=CC3C=C4C(=CC3C=C1C21CCCCC1)c1sc(C=C2C(=O)C(=O)c3ccccc32)cc1C41CCCCC1
外观性状	ammonium sulfate suspension
储存条件	2-8°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3

Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.

Bioorg. Med. Chem. 16 , 1084-9, (2008)

Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p...

Enzyme biosensor for androsterone based on 3α-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode.

Talanta 99 , 697-702, (2012)

A 3α-hydrosteroid biosensor for androsterone determination has been prepared by immobilizing the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD) in a composite electrode platform constituted of a mixt...

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Biochem. Biophys. Res. Commun. 148(2) , 646-52, (1987)

Homogeneous 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) from rat liver cytosol displays 9, 11, and 15-hydroxyprostaglandin dehydrogenase activity. Using [14C]-PGF2 alpha as substrate the produc...

ALPHA-HYDROXYSTEROID DEHYDROGENASE

3ALPHA-HYDROXYSTEROID: NAD[P]+ OXIDOREDUCTASE

EC 1.1.1.50

EC: 1.1.1.50

3alpha-hydroxysteroid dehydrogenase F. pseu. test. ~9 U/mg

3alpha-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni

Dehydrogenase, 3alpha-hydroxy steroid