3alpha-hydroxysteroid dehydrogenase

Modify Date: 2024-01-06 19:45:48

3alpha-hydroxysteroid dehydrogenase Structure
3alpha-hydroxysteroid dehydrogenase structure
Common Name 3alpha-hydroxysteroid dehydrogenase
CAS Number 9028-56-2 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS USA Flash Point N/A

 Use of 3alpha-hydroxysteroid dehydrogenase


3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism[1].

 Names

Name Dehydrogenase 3alpha-hydroxy steroid
Synonym More Synonyms

 3alpha-hydroxysteroid dehydrogenase Biological Activity

Description 3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism[1].
Related Catalog
References

[1]. Anne Z Steiner, et al. 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr;93(4):1298-303.   

 Chemical & Physical Properties

Appearance of Characters ammonium sulfate suspension
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles29

More Articles
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.

Bioorg. Med. Chem. 16 , 1084-9, (2008)

Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p...

Enzyme biosensor for androsterone based on 3α-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode.

Talanta 99 , 697-702, (2012)

A 3α-hydrosteroid biosensor for androsterone determination has been prepared by immobilizing the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD) in a composite electrode platform constituted of a mixt...

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Biochem. Biophys. Res. Commun. 148(2) , 646-52, (1987)

Homogeneous 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) from rat liver cytosol displays 9, 11, and 15-hydroxyprostaglandin dehydrogenase activity. Using [14C]-PGF2 alpha as substrate the produc...

 Synonyms

ALPHA-HYDROXYSTEROID DEHYDROGENASE
3ALPHA-HYDROXYSTEROID: NAD[P]+ OXIDOREDUCTASE
EC 1.1.1.50
EC: 1.1.1.50
3alpha-hydroxysteroid dehydrogenase F. pseu. test. ~9 U/mg
3alpha-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni
Dehydrogenase, 3alpha-hydroxy steroid