托格列净

更新时间：2025-08-27 05:43:44

托格列净结构式	常用名	托格列净	英文名	Tofogliflozin
	CAS号	903565-83-3	分子量	386.43800
	密度	N/A	沸点	N/A
	分子式	C₂₂H₂₆O₆	熔点	N/A
	MSDS	N/A	闪点	N/A

托格列净用途

Tofogliflozin(CSG-452)是SGLT2高效选择性抑制剂,对人源、大鼠和小鼠SGLT2的Ki值分别为2.9、14.9和6.4nM。

中文名	托格列净
英文名	(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
英文别名	更多

描述	Tofogliflozin(CSG-452)是SGLT2高效选择性抑制剂,对人源、大鼠和小鼠SGLT2的Ki值分别为2.9、14.9和6.4nM。
相关类别	信号通路 >> 跨膜转运 >> SGLT 研究领域 >> 代谢疾病
参考文献	[1]. Nagata T, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-31. [2]. Yamane M, et al. In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP. Xenobioti [3]. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701. [4]. Nagata T, et al. Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

描述

Tofogliflozin(CSG-452)是SGLT2高效选择性抑制剂,对人源、大鼠和小鼠SGLT2的Ki值分别为2.9、14.9和6.4nM。

相关类别

信号通路 >> 跨膜转运 >> SGLT

研究领域 >> 代谢疾病

参考文献

[1]. Nagata T, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-31.

[2]. Yamane M, et al. In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP. Xenobioti

[3]. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

[4]. Nagata T, et al. Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

分子式	C₂₂H₂₆O₆
分子量	386.43800
精确质量	386.17300
PSA	99.38000
LogP	0.99660
InChIKey	VWVKUNOPTJGDOB-BDHVOXNPSA-N
SMILES	CCc1ccc(Cc2ccc3c(c2)C2(OC3)OC(CO)C(O)C(O)C2O)cc1
储存条件	2-8℃

实验名称：Human Sodium/glucose cotransporter 2 (Hexose transporter family)
来源：IUPHAR-DB
靶标：Sodium/glucose cotransporter 2 (Hexose transporter family) [Homo sapiens]
External Id：916_Human

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
来源：NCGC
靶标：N/A
External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
来源：NCGC
External Id：TRND-SARS-CoV-2-PP

实验名称：Human Sodium/glucose cotransporter 1 (Hexose transporter family)
来源：IUPHAR-DB
靶标：Sodium/glucose cotransporter 1 (Hexose transporter family) [Homo sapiens]
External Id：915_Human

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t...
来源：NCGC
靶标：N/A
External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit...
来源：NCGC
External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni...
来源：NCGC
靶标：N/A
External Id：CPF001

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans...
来源：NCGC
External Id：MTASE-p

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