5'-脱氧-5-氟-N-[(2-甲基丁氧基)羰基]胞苷

• 常用名: 5'-脱氧-5-氟-N-[(2-甲基丁氧基)羰基]胞苷
• 英文名: 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine
• CAS号: 910129-15-6
• 分子量: 359.35
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₅H₂₂FN₃O₆
• 熔点: 62-64°C
• 闪点: N/A

用途

5′-脱氧-5-氟-N-[(2-甲基丁氧基)羰基]胞苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 5'-脱氧-5-氟-N-[(2-甲基丁氧基)羰基]胞苷
• 英文名: 2-methylbutyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

生物活性

• 描述: 5′-脱氧-5-氟-N-[(2-甲基丁氧基)羰基]胞苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 熔点: 62-64°C
• 分子式: C₁₅H₂₂FN₃O₆
• 分子量: 359.35
• 精确质量: 359.149261
• PSA: 126.40000
• LogP: 0.97
• InChIKey: WBAXSXXYPPILCT-DGHYOTGBSA-N
• SMILES: CCC(C)COC(=O)Nc1nc(=O)n(C2OC(C)C(O)C2O)cc1F
• 折射率: 1.600
• 储存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

安全信息

• 危害码 (欧洲): Xn

靶点实验

查看更多实验

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英文别名

• unii-0jd5qg20w5
• 1-(5-Deoxypentofuranosyl)-5-fluoro-4-{[(pentyloxy)carbonyl]amino}-2(1H)-pyrimidinone
• 1-(5-deoxypentofuranosyl)-5-fluoro-4-{[(pentyloxy)carbonyl]amino}pyrimidin-2(1h)-one
• 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine
• Capecitabine Impurity 2