TCS 1102

• 常用名: TCS 1102
• 英文名: TCS 1102
• CAS号: 916141-36-1
• 分子量: 470.58600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₆N₄O₂S
• 熔点: N/A
• 闪点: N/A

TCS 1102用途

TCS 1102是食欲肽OX受体拮抗剂，对OX2和OX1受体的Ki分别为0.2和3 nM。

TCS 1102名称

• 中文名: TCS 1102
• 英文名: N-2-Biphenylyl-1-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl }-L-prolinamide

TCS 1102生物活性

• 描述: TCS 1102是食欲肽OX受体拮抗剂,对OX2和OX1受体的Ki分别为0.2和3 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 食欲素受体(OX受体)
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bergman JM, et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1425-30.

  [2]. Chen X, et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct Funct. 2013 Aug 18.

TCS 1102物理化学性质

• 分子式: C₂₇H₂₆N₄O₂S
• 分子量: 470.58600
• 精确质量: 470.17800
• PSA: 96.02000
• LogP: 5.54950
• InChIKey: YSBGRVXJEMSEQY-DEOSSOPVSA-N
• SMILES: Cn1c(SCC(=O)N2CCCC2C(=O)Nc2ccccc2-c2ccccc2)nc2ccccc21
• 储存条件: -20°C，密闭，干燥

TCS 1102靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membran... 来源：ChEMBL 靶标：Orexin receptor type 2 External Id：CHEMBL4429656

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Human OX1 receptor (Orexin receptors) 来源：IUPHAR-DB 靶标：OX1 receptor (Orexin receptors) [Homo sapiens] External Id：321_Human

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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TCS 1102英文别名

• TCS 1102