N2-[4-(氨基甲基)苯基]-5-氟-N4-苯基嘧啶-2,4-二胺

• 常用名: N2-[4-(氨基甲基)苯基]-5-氟-N4-苯基嘧啶-2,4-二胺
• 英文名: CZC8004
• CAS号: 916603-07-1
• 分子量: 309.341
• 密度: 1.3±0.1 g/cm3
• 沸点: 514.1±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₅
• 熔点: N/A
• 闪点: 264.7±32.9 °C

用途

CZC-8004 是一种广泛的激酶抑制剂,可与多种酪氨酸激酶结合,包括 ABL 激酶。

名称

• 中文名: N2-(4-(氨甲基)苯)-5-氟-N4-苯基嘧啶-2,4-二胺
• 英文名: N2-(4-(Aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-diamine
• 中文别名: N2-[4-(氨基甲基)苯基]-5-氟-n4-苯基嘧啶-2,4-二胺

生物活性

• 描述: CZC-8004 是一种广泛的激酶抑制剂,可与多种酪氨酸激酶结合,包括 ABL 激酶。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BCR-ABL
  研究领域 >> 癌症
• 参考文献:

  [1]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC₅₀ values for tyrosine kinase.

  [2]. Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 514.1±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₅
• 分子量: 309.341
• 闪点: 264.7±32.9 °C
• 精确质量: 309.138977
• PSA: 75.86000
• LogP: 2.27
• InChIKey: UKOHFWNBTUJMMN-UHFFFAOYSA-N
• SMILES: NCc1ccc(Nc2ncc(F)c(Nc3ccccc3)n2)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.699
• 储存条件: 2-8°C，避光，保存于惰性气体中

安全信息

• 海关编码: 2921499090

海关

• 海关编码: 2921499090
• 中文概述: 2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

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英文别名

• N-[4-(Aminomethyl)phenyl]-5-fluoro-N-phenyl-2,4-pyrimidinediamine
• CZC8004
• 2-N-[4-(aminomethyl)phenyl]-5-fluoro-4-N-phenylpyrimidine-2,4-diamine