Recilisib sodium

• 常用名: Recilisib sodium
• 英文名: Recilisib sodium
• CAS号: 922139-31-9
• 分子量: 358.77
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₂ClNaO₄S
• 熔点: N/A
• 闪点: N/A

Recilisib sodium用途

Recilisib钠(ON 01210)是一种放射性保护剂,可激活细胞中的AKT、PI3K活性[1]。

Recilisib sodium名称

• 英文名: sodium,4-[(E)-2-[(4-chlorophenyl)methylsulfonyl]ethenyl]benzoate

Recilisib sodium生物活性

• 描述: Recilisib钠(ON 01210)是一种放射性保护剂,可激活细胞中的AKT、PI3K活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 体外研究: Recilisib钠(高达50μM)在整个细胞周期中显示出细胞的正常分布,在50μM时S期细胞数量略有减少。连续暴露Recilisib钠(100μM)不会导致细胞死亡。Recilisib钠治疗不会抑制人类骨髓细胞的集落形成潜力。Recilisib钠在所有三种剂量的IR下都能对人类骨髓细胞提供剂量依赖性保护。Recilimab钠激活HFL细胞中AKT和GSK3α/β的磷酸化。Recilisib钠增加HFL-1细胞和小鼠骨髓细胞对辐射暴露的PI3K活性。Recilisib钠与辐射联合治疗可改变MAPK信号通路[1]。
• 体内研究: Recilisib钠(500mg/kg)显著提高小鼠原始骨髓髓系祖细胞的恢复和分化率。Recilisib钠与辐射联合使用可降低小鼠的CFU数量,但Recilimab钠治疗的小鼠始终保持形成分化菌落的能力。Recilisib钠治疗的小鼠的祖细胞群从未因辐射暴露而完全耗尽[1]。
• 参考文献:

  [1]. Kang AD, et al. ON01210.Na (Ex-RAD) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355.

Recilisib sodium物理化学性质

• 分子式: C₁₆H₁₂ClNaO₄S
• 分子量: 358.77
• 精确质量: 358.00400
• PSA: 82.65000
• LogP: 3.37000
• InChIKey: PRFBWBYKWZVQJF-RRABGKBLSA-M
• SMILES: O=C([O-])c1ccc(C=CS(=O)(=O)Cc2ccc(Cl)cc2)cc1.[Na+]

Recilisib sodium靶点实验

查看更多实验

实验名称：Induction of apoptosis in human AHH-1 cells assessed as necrotic cells preincubated w... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507854

实验名称：Induction of apoptosis in human AHH-1 cells assessed as late apoptotic cells preincub... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507853

实验名称：Induction of apoptosis in human AHH-1 cells assessed as early apoptotic cells preincu... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507852

实验名称：Induction of apoptosis in human AHH-1 cells assessed as viable cells preincubated wit... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507851

实验名称：Induction of apoptosis in human AHH-1 cells assessed as necrotic cells preincubated w... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507850

实验名称：Induction of apoptosis in human AHH-1 cells assessed as late apoptotic cells preincub... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507849

实验名称：Induction of apoptosis in human AHH-1 cells assessed as early apoptotic cells preincu... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507848

实验名称：Induction of apoptosis in human AHH-1 cells assessed as viable cells preincubated wit... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507847

实验名称：Induction of apoptosis in human AHH-1 cells assessed as necrotic cells preincubated w... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507846

实验名称：Induction of apoptosis in human AHH-1 cells assessed as late apoptotic cells preincub... 来源：ChEMBL 靶标：AHH-1 External Id：CHEMBL5507845

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Recilisib sodium英文别名

• Ex-Rad
• UNII-1068SXU525
• Recilisib sodium