RRX-001

• 常用名: RRX-001
• 英文名: RRx-001
• CAS号: 925206-65-1
• 分子量: 268.02200
• 密度: N/A
• 沸点: N/A
• 分子式: C₅H₆BrN₃O₅
• 熔点: N/A
• 闪点: N/A

RRX-001用途

RRX-001是一种有效的葡萄糖-6-磷酸脱氢酶 (G6PD) 抑制剂。 RRX-001具有强抗疟效果, 药物敏感性测试表明, 抑制寄生虫活性IC50 = 0.14 ± 0.04 ug/ml。

RRX-001名称

• 中文名: RRX-001
• 英文名: 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone

RRX-001生物活性

• 描述: RRX-001是一种有效的葡萄糖-6-磷酸脱氢酶 (G6PD) 抑制剂。 RRX-001具有强抗疟效果, 药物敏感性测试表明, 抑制寄生虫活性IC50 = 0.14 ± 0.04 ug/ml。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May 28;14:218.

  [2]. Scicinski J, et al. Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent. Drug Metab Dispos. 2012 Sep;40(9):1810-1816.

RRX-001物理化学性质

• 分子式: C₅H₆BrN₃O₅
• 分子量: 268.02200
• 精确质量: 266.94900
• PSA: 111.95000
• LogP: 0.45750
• InChIKey: JODKFOVZURLVTG-UHFFFAOYSA-N
• SMILES: O=C(CBr)N1CC([N+](=O)[O-])([N+](=O)[O-])C1
• 外观性状: 粉末
• 储存条件: -20℃

RRX-001安全信息

• 危害码 (欧洲): N

RRX-001靶点实验

查看更多实验

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Drug metabolism in rat whole blood assessed as [(R)-2-amino-3-((2-(3-nitroazetidin-1-... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541626

实验名称：Drug metabolism in human whole blood assessed as [(R)-2-(2-amino-3-((2-(3,3-dinitroaz... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541627

实验名称：Drug metabolism in rat whole blood assessed as [(S)-2-amino-5-(((R)-1-((carboxymethyl... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541624

实验名称：Drug metabolism in human whole blood assessed as [(R)-2-amino-3-((2-(3-nitroazetidin-... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541625

实验名称：Drug metabolism in rat whole blood assessed as [(S)-2-amino-5-(((R)-1-((carboxymethyl... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541630

实验名称：Drug metabolism in human whole blood assessed as [(S)-2-amino-5-(((R)-1-((carboxymeth... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541631

实验名称：Drug metabolism in rat whole blood assessed as [(R)-2-(2-amino-3-((2-(3,3-dinitroazet... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541628

实验名称：Drug metabolism in human whole blood assessed as [(S)-2-amino-5-(((R)-1-((carboxymeth... 来源：ChEMBL 靶标：Whole blood External Id：CHEMBL3541629

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RRX-001英文别名

• RRX-001
• UNII-7RPW6SU9SC
• 1-bromoacetyl-3,3-dinitroazetidine
• 2-Bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one