Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]

• 常用名: Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]
• 英文名: Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]
• CAS号: 927822-45-5
• 分子量: 343.33728
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇N₅O₄
• 熔点: N/A
• 闪点: N/A

用途

UC-1V150是一种特异性TLR7(Toll样受体)激动剂,刺激细胞免疫反应并具有抗肿瘤活性。UC-1V150可用于合成ISAC(免疫刺激抗体结合物)分子[1][2]。

名称

• 英文名: Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]

生物活性

• 描述: UC-1V150是一种特异性TLR7(Toll样受体)激动剂,刺激细胞免疫反应并具有抗肿瘤活性。UC-1V150可用于合成ISAC(免疫刺激抗体结合物)分子[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 炎症/免疫
• 靶点实验:

  TLR7

• 体外研究: UC-1V150(0.01-10μM,24小时)能有效刺激骨髓源性巨噬细胞释放IL-6和IL-2细胞因子[1]。UC-1V150(1μg/mL,48小时)可增加FcγRIIA和FcγRIII的表达,同时诱导人单核细胞源性巨噬细胞(hMDM)靶细胞的巨噬细胞吞噬指数增加约1.5倍[2]。
• 体内研究: UC-1V150(静脉注射,0.38-38 nM,一次,2小时)有效诱导雌性C57BL/6小鼠(5-6周龄)在一定浓度范围内释放血清细胞因子[1]。动物模型：雌性C57BL/6小鼠(5-6周龄)[1]剂量：0.38-38 nM给药：静脉注射；一旦2小时结果：在38 nM浓度下诱导血清细胞因子IL-6水平约为0.1 ng/mL,IL-2水平约为1.5 ng/mL。
• 参考文献:

  [1]. Christina C N Wu, et al. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3990-5.

  [2]. L N Dahal, et al. UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion. Scand J Immunol. 2018 Jun;87(6):e12666.

物理化学性质

• 分子式: C₁₆H₁₇N₅O₄
• 分子量: 343.33728
• InChIKey: SHNIBVWXUOEWTA-UHFFFAOYSA-N
• SMILES: COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(C=O)cc3)c2n1

靶点实验

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