ML-191

• 常用名: ML-191
• 英文名: ML-191
• CAS号: 931695-79-3
• 分子量: 403.474
• 密度: 1.3±0.1 g/cm3
• 沸点: 569.5±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅N₃O₃
• 熔点: N/A
• 闪点: 298.2±32.9 °C

ML-191用途

ML-191是GPR55的拮抗剂。它抑制溶血磷脂酰肌醇诱导的GPR55信号传导(在过度表达GPR55的U2OS细胞中EC50=1.076µM)。当使用浓度为30µM时,ML-191抑制LPI诱导的ERK1/2磷酸化(IC50=328 nM)和PKCβII的受体依赖性转位[1]。

ML-191名称

• 英文名: 3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-p henyl-1,3,4-oxadiazol-2(3H)-one

ML-191生物活性

• 描述: ML-191是GPR55的拮抗剂。它抑制溶血磷脂酰肌醇诱导的GPR55信号传导(在过度表达GPR55的U2OS细胞中EC50=1.076µM)。当使用浓度为30µM时,ML-191抑制LPI诱导的ERK1/2磷酸化(IC50=328 nM)和PKCβII的受体依赖性转位[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR55
• 参考文献:

  [1]. Heynen-Genel S, et al. Screening for Selective Ligands for GPR55 - Antagonists. 2010 Oct 30

ML-191物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 569.5±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅N₃O₃
• 分子量: 403.474
• 闪点: 298.2±32.9 °C
• 精确质量: 403.189606
• PSA: 68.34000
• LogP: 2.75
• InChIKey: WWJKJCDOYFKZBJ-UHFFFAOYSA-N
• SMILES: Cc1ccc(C2(C(=O)N3CCC(n4nc(-c5ccccc5)oc4=O)CC3)CC2)cc1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.668
• 储存条件: -20°C，密闭，干燥

ML-191靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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ML-191英文别名

• 3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-phenyl-1,3,4-oxadiazol-2(3H)-one