PPQ-102

• 常用名: PPQ-102
• 英文名: PPQ 102
• CAS号: 931706-15-9
• 分子量: 438.478
• 密度: 1.4±0.1 g/cm3
• 沸点: 648.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₃
• 熔点: N/A
• 闪点: 346.1±34.3 °C

PPQ-102用途

PPQ-102是CFTR抑制剂,能抑制CFTR氯流,IC50为90 nM。

PPQ-102名称

• 中文名: PPQ-102
• 英文名: 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4 ',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

PPQ-102生物活性

• 描述: PPQ-102是CFTR抑制剂,能抑制CFTR氯流,IC50为90 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 其他
• 参考文献:

  [1]. Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.

  [2]. Stewart AK, et al. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug;301(2):C289-303.

  [3]. Martin C, et al. CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur Respir J. 2013 Dec;42(6):1553-62.

PPQ-102物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 648.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₃
• 分子量: 438.478
• 闪点: 346.1±34.3 °C
• 精确质量: 438.169189
• PSA: 74.10000
• LogP: 3.48
• InChIKey: MNOOVRNGPIWJDI-UHFFFAOYSA-N
• SMILES: Cc1ccc(C2Nc3ccccc3-n3c(-c4ccccc4)c4c(=O)n(C)c(=O)n(C)c4c32)o1
• 外观性状: white solid
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.720
• 储存条件: -20℃

PPQ-102靶点实验

查看更多实验

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：qHTS Assay for Inhibitors of Human Galactokinase (GALK): NCGC Sytravon Library Screen 来源：NCGC 靶标：galactokinase 1 [Homo sapiens] External Id：galk-p7-sytravon

实验名称：Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter A... 来源：NCGC External Id：huntington-HTT2-p1-FF-overN

实验名称：Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of IBMX-in... 来源：ChEMBL 靶标：Cystic fibrosis transmembrane conductance regulator External Id：CHEMBL1228131

实验名称：Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of apigeni... 来源：ChEMBL 靶标：Cystic fibrosis transmembrane conductance regulator External Id：CHEMBL1228130

实验名称：Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of CPT-cAM... 来源：ChEMBL 靶标：Cystic fibrosis transmembrane conductance regulator External Id：CHEMBL1227954

实验名称：Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP... 来源：ChEMBL 靶标：Cystic fibrosis transmembrane conductance regulator External Id：CHEMBL1227952

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PPQ-102英文别名

• 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
• 7.9-Dimethylxanthin
• 7,9-dimethoxy-5H-pyrido<3,2-c>azepine
• 7,9-dimethylxanthine
• 7,9-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium betaine
• 7,9-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium-betain
• 7,9-dimethoxy-5H-pyrido<3,2-c>-azephine
• 3,9-dimethylxanthine
• PPQ-102