(2S,5R)-5-(4-((2-氟苄基)氧基)苯基)吡咯烷-2-甲酰胺

• 常用名: (2S,5R)-5-(4-((2-氟苄基)氧基)苯基)吡咯烷-2-甲酰胺
• 英文名: CNV1014802
• CAS号: 934240-30-9
• 分子量: 314.35400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₉FN₂O₂
• 熔点: N/A
• 闪点: N/A

用途

CNV1014802(GSK-1014802)是钠离子通道Nav1.7有效抑制剂。

名称

• 中文名: Raxatrigine
• 英文名: (5R)-5-{4-[(2-Fluorobenzyl)oxy]phenyl}-L-prolinamide

生物活性

• 描述: CNV1014802(GSK-1014802)是钠离子通道Nav1.7有效抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Large CH, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J Pharmacol Exp Ther. 2011 Jul;338(1):100-13.

物理化学性质

• 分子式: C₁₈H₁₉FN₂O₂
• 分子量: 314.35400
• 精确质量: 314.14300
• PSA: 65.34000
• LogP: 4.16160
• InChIKey: JESCETIFNOFKEU-SJORKVTESA-N
• SMILES: NC(=O)C1CCC(c2ccc(OCc3ccccc3F)cc2)N1
• 储存条件: 2-8°C，避光，保存于惰性气体中

靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.5 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322002

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.4 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322001

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.3 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322000

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.2 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4321999

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.1 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4321998

实验名称：Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 10 subunit alpha External Id：CHEMBL4321997

实验名称：Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 8 subunit alpha External Id：CHEMBL4321996

实验名称：Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4321995

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

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英文别名

• CNV1014802