TY-52156

• 常用名: TY-52156
• 英文名: TY-52156
• CAS号: 934369-14-9
• 分子量: 364.26900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₉Cl₂N₃O
• 熔点: N/A
• 闪点: N/A

TY-52156用途

TY-52156是一种有效的S1P3受体拮抗剂,作用于S1P3受体Ki值为110 nM。

TY-52156名称

• 中文名: TY-52156
• 英文名: 1-(4-chlorophenylamino)-1-(4-chlorophenylhydrazono)-3,3-dimethyl-2-butanone

TY-52156生物活性

• 描述: TY-52156是一种有效的S1P3受体拮抗剂,作用于S1P3受体Ki值为110 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Murakami A, et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13.

TY-52156物理化学性质

• 分子式: C₁₈H₁₉Cl₂N₃O
• 分子量: 364.26900
• 精确质量: 363.09100
• PSA: 53.49000
• LogP: 5.59210
• InChIKey: XONRRGIRSGNWFP-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(=O)C(=Nc1ccc(Cl)cc1)NNc1ccc(Cl)cc1
• 储存条件: 2-8℃

TY-52156靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antagonist activity at human S1P3 receptor expressed in CHO cells assessed as inhibit... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 3 External Id：CHEMBL5576345

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antagonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as redu... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 3 External Id：CHEMBL5576381

实验名称：Antagonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as redu... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 1 External Id：CHEMBL5576382

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Antagonist activity at human S1P2 receptor expressed in CHO-K1 cells assessed as redu... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 2 External Id：CHEMBL5576383

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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TY-52156英文别名

• ty52156
• TY-52156