TY-52156
Modify Date: 2024-01-20 12:53:30
TY-52156 structure
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Common Name | TY-52156 | ||
|---|---|---|---|---|
| CAS Number | 934369-14-9 | Molecular Weight | 364.26900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19Cl2N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TY-52156TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor.IC50 value: 110 nM (Ki)Target: S1P3in vitro: TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor. TY-52156 is both sensitive and useful as an S1P3 receptor-specific antagonist and reveal that S1P induces vasoconstriction by directly activating S1P3 receptor and through a subsequent increase in [Ca2+]i and Rho activation in vascular smooth muscle cells. TY-52156 has a selective antagonistic effect toward S1P3 receptor. [1]in vivo: TY-52156 Suppresses S1P3 Receptor-Induced Bradycardia In Vivo. the oral administration of TY-52156 inhibits S1P3 receptor-dependent bradycardia. [1] |
| Name | 1-(4-chlorophenylamino)-1-(4-chlorophenylhydrazono)-3,3-dimethyl-2-butanone |
|---|---|
| Synonym | More Synonyms |
| Description | TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor.IC50 value: 110 nM (Ki)Target: S1P3in vitro: TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor. TY-52156 is both sensitive and useful as an S1P3 receptor-specific antagonist and reveal that S1P induces vasoconstriction by directly activating S1P3 receptor and through a subsequent increase in [Ca2+]i and Rho activation in vascular smooth muscle cells. TY-52156 has a selective antagonistic effect toward S1P3 receptor. [1]in vivo: TY-52156 Suppresses S1P3 Receptor-Induced Bradycardia In Vivo. the oral administration of TY-52156 inhibits S1P3 receptor-dependent bradycardia. [1] |
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| Related Catalog | |
| References |
| Molecular Formula | C18H19Cl2N3O |
|---|---|
| Molecular Weight | 364.26900 |
| Exact Mass | 363.09100 |
| PSA | 53.49000 |
| LogP | 5.59210 |
| Storage condition | 2-8℃ |
| ty52156 |
| TY-52156 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TY-52156
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: TY-52156
- Price: $1800.0/1g $950.0/250mg $500.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TY-52156
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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Price: $79/10mM*1mLinDMSO
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