AZD-6280

• 常用名: AZD-6280
• 英文名: AZD-6280
• CAS号: 942436-93-3
• 分子量: 366.41400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₂N₄O₃
• 熔点: N/A
• 闪点: N/A

AZD-6280用途

AZD-6280 是具有选择性的 GABAA(α2/3) 受体调节剂,用于治疗广泛性焦虑症。

AZD-6280名称

• 中文名: AZD-6280
• 英文名: 4-amino-8-(2,5-dimethoxyphenyl)-N-propylcinnoline-3-carboxamide

AZD-6280生物活性

• 描述: AZD-6280 是具有选择性的 GABAA(α2/3) 受体调节剂,用于治疗广泛性焦虑症。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Te Beek ET, et al. The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54. doi: 10.1002/cpdd.134. Epub 2014 Aug 28.

AZD-6280物理化学性质

• 分子式: C₂₀H₂₂N₄O₃
• 分子量: 366.41400
• 精确质量: 366.16900
• PSA: 102.85000
• LogP: 4.19200
• 储存条件: 2-8℃

AZD-6280靶点实验

查看更多实验

实验名称：Binding affinity to GABA-A alpha3 (unknown origin) assessed as increase in induced cu... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL4403725

实验名称：Binding affinity to GABA-A alpha5 (unknown origin) assessed as increase in induced cu... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-5 External Id：CHEMBL4403726

实验名称：Binding affinity to GABA-A alpha2 (unknown origin) 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-2 External Id：CHEMBL4403717

实验名称：Binding affinity to GABA-A alpha1 (unknown origin) 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL4403718

实验名称：Binding affinity to GABA-A alpha3 (unknown origin) 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL4403719

实验名称：Binding affinity to GABA-A alpha5 (unknown origin) 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-5 External Id：CHEMBL4403720

实验名称：Binding affinity to GABA-A alpha1 (unknown origin) assessed as increase in induced cu... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL4403723

实验名称：Binding affinity to GABA-A alpha2 (unknown origin) assessed as increase in induced cu... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-2 External Id：CHEMBL4403724

实验名称：Solubility of the compound in DMSO by LC/MS/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL1787626

实验名称：Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3g... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-2 External Id：CHEMBL1787625

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AZD-6280英文别名

• unii-b9z1oeh19d
• azd-6280