Chlorahololide D

• 常用名: Chlorahololide D
• 英文名: Chlorahololide D
• CAS号: 943136-39-8
• 分子量: 676.749
• 密度: 1.4±0.1 g/cm3
• 沸点: 833.7±65.0 °C at 760 mmHg
• 分子式: C₃₈H₄₄O₁₁
• 熔点: N/A
• 闪点: 259.4±27.8 °C

Chlorahololide D用途

氯磺酰脲D是一种强效选择性钾通道阻滞剂,IC50值为2.7µM。chlorololide D是一种天然产物,可以从全草中分离出来[1]。

Chlorahololide D名称

• 英文名: Chlorahololide D

Chlorahololide D生物活性

• 描述: 氯磺酰脲D是一种强效选择性钾通道阻滞剂,IC50值为2.7µM。chlorololide D是一种天然产物,可以从全草中分离出来[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Ping YS, et, al. Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb 25;64(9): 2027-34.

Chlorahololide D物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 833.7±65.0 °C at 760 mmHg
• 分子式: C₃₈H₄₄O₁₁
• 分子量: 676.749
• 闪点: 259.4±27.8 °C
• 精确质量: 676.288391
• PSA: 162.73000
• LogP: 3.08
• InChIKey: WZKZSZYDBUUHLB-UHFFFAOYSA-N
• SMILES: CC=C(C)C(=O)OCC1(O)C2CC2C2(C)C1CC1=C(COC(C)=O)C(=O)OC13C1C(=C(C)C(=O)OC)C(=O)C(O)C4(C)C1=C(CC32)C1CC14
• 外观性状: 粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.630
• 储存条件: 2-8℃，干燥，密闭

Chlorahololide D安全信息

• 危害码 (欧洲): Xi

Chlorahololide D靶点实验

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实验名称：Antifungal activity against Fusarium oxysporum after 48 to 72 hr by agar dilution met... 来源：ChEMBL 靶标：Fusarium oxysporum External Id：CHEMBL3048425

实验名称：Antifungal activity against Botryotinia fuckeliana after 48 to 72 hr by agar dilution... 来源：ChEMBL 靶标：Botrytis cinerea External Id：CHEMBL3048426

实验名称：Antifungal activity against Alternaria kikuchiana after 48 to 72 hr by agar dilution ... 来源：ChEMBL 靶标：Alternaria kikuchiana External Id：CHEMBL3048427

实验名称：Antifungal activity against Blumeria graminis f. sp. hordei infected compound pre-tre... 来源：ChEMBL 靶标：Blumeria hordei External Id：CHEMBL3047693

实验名称：Antifungal activity against Blumeria graminis f. sp. hordei infected compound pre-tre... 来源：ChEMBL 靶标：Blumeria hordei External Id：CHEMBL3047694

实验名称：Antifungal activity against Blumeria graminis f. sp. hordei infected compound pre-tre... 来源：ChEMBL 靶标：Blumeria hordei External Id：CHEMBL3047695

实验名称：Antifungal activity against Magnaporthe grisea infected compound pre-treated rice pla... 来源：ChEMBL 靶标：Pyricularia grisea External Id：CHEMBL3048710

实验名称：Antifungal activity against Magnaporthe grisea infected compound pre-treated rice pla... 来源：ChEMBL 靶标：Pyricularia grisea External Id：CHEMBL3048711

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as cellular metabolic activity at ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4334207

实验名称：Antifungal activity against Magnaporthe grisea infected compound pre-treated rice pla... 来源：ChEMBL 靶标：Pyricularia grisea External Id：CHEMBL3048117

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Chlorahololide D英文别名

• [(1aR,1bS,2R,4Z,8aR,9S,9aS,10aR,10bS,10cS,11bS)-7-(Acetoxymethyl)-2,9-dihydroxy-4-(1-methoxy-1-oxo-2-propanylidene)-1b,10b-dimethyl-3,6-dioxo-1,1a,1b,2,3,4,4a,6,8,8a,9,9a,10,10a,10b,10c,11,11b-octadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-9-yl]methyl (2E)-2-methyl-2-butenoate