Antiviral agent 34

• 常用名: Antiviral agent 34
• 英文名: Antiviral agent 34
• CAS号: 945152-88-5
• 分子量: 487.66
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₃N₃O₂S
• 熔点: N/A
• 闪点: N/A

Antiviral agent 34用途

Antiviral agent 34 是一种强效且口服有效的抗甲型和乙型流感亚型抗病毒药物,对 H1N1 增殖的 EC50 值为 0.8 nM。Antiviral agent 34 通过靶向流感病毒 RNA 依赖性 RNA 聚合酶来抑制流感病毒的增殖。Antiviral agent 34 可用于流感病毒的研究。

Antiviral agent 34名称

• 英文名: Antiviral agent 34

Antiviral agent 34生物活性

• 描述: Antiviral agent 34 是一种强效且口服有效的抗甲型和乙型流感亚型抗病毒药物,对 H1N1 增殖的 EC50 值为 0.8 nM。Antiviral agent 34 通过靶向流感病毒 RNA 依赖性 RNA 聚合酶来抑制流感病毒的增殖。Antiviral agent 34 可用于流感病毒的研究。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 参考文献:

  [1]. Liu X, et al. Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors. Eur J Med Chem. 2023 Nov 5;259:115678.

Antiviral agent 34物理化学性质

• 分子式: C₂₉H₃₃N₃O₂S
• 分子量: 487.66
• InChIKey: GKGUZBBYDHKNIJ-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1ccc(C(=O)NC(=S)Nc2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)cc2)cc1

Antiviral agent 34靶点实验

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实验名称：Antiviral activity against Influenza A virus H1N1 (A/Puerto Rico/8/34) infected in MD... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627538

实验名称：Cytotoxicity against MDCK cells by CCK-8 assay 来源：ChEMBL 靶标：MDCK External Id：CHEMBL5627539

实验名称：Selectivity index, ratio of CC50 for MDCK cells to EC50 for antiviral activity agains... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627540

实验名称：Half life in Sprague-Dawley rat at 3 mg/kg, iv measured up to 24 hrs by LC-MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627541

实验名称：Half life in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627542

实验名称：Tmax in Sprague-Dawley rat at 3 mg/kg, iv measured up to 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627543

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627544

实验名称：Cmax in Sprague-Dawley rat at 3 mg/kg, iv measured up to 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627545

实验名称：Cmax in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627546

实验名称：AUC(0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627547

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