SJ000063181

• 常用名: SJ000063181
• 英文名: SJ000063181
• CAS号: 945189-68-4
• 分子量: 296.72
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₄ClFN₂O₂
• 熔点: N/A
• 闪点: N/A

SJ000063181用途

SJ00006181是一种有效的BMP信号激活剂,具有EC50≤1µM。SJ000063181可以用作化学探针来询问BMP信号,因为它可以穿透斑马鱼胚胎[1]。

SJ000063181名称

• 英文名: SJ000063181

SJ000063181生物活性

• 描述: SJ00006181是一种有效的BMP信号激活剂,具有EC50≤1µM。SJ000063181可以用作化学探针来询问BMP信号,因为它可以穿透斑马鱼胚胎[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> TGF-β/Smad蛋白
  信号通路 >> TGF-beta/Smad 信号通路 >> TGF-β/Smad蛋白
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Jamie R Genthe, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol.2019 Jul 19;14(7):1673.

SJ000063181物理化学性质

• 分子式: C₁₄H₁₄ClFN₂O₂
• 分子量: 296.72
• InChIKey: PBZNVOPQXYXTPC-UHFFFAOYSA-N
• SMILES: CC(C)Cc1cc(C(=O)Nc2ccc(F)c(Cl)c2)no1

SJ000063181靶点实验

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实验名称：Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter... 来源：ChEMBL 靶标：Survival motor neuron protein External Id：CHEMBL4021909

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter... 来源：ChEMBL 靶标：Survival motor neuron protein External Id：CHEMBL4021910

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