ZIKV-IN-3

• 常用名: ZIKV-IN-3
• 英文名: ZIKV-IN-3
• CAS号: 947699-46-9
• 分子量: 587.75
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₉H₄₁NO₄
• 熔点: N/A
• 闪点: N/A

ZIKV-IN-3用途

ZIKV-IN-3(化合物5a)是一种穿心莲内酯衍生物,是一种有效的ZIKV NS5甲基转移酶(MTase)抑制剂,IC50值为18.34μM。ZIKV-IN-3抑制ZIKV复制和感染。ZIKV-IN-3可用于寨卡病毒(ZIKV)的研究[1]。

ZIKV-IN-3名称

• 英文名: ZIKV-IN-3

ZIKV-IN-3生物活性

• 描述: ZIKV-IN-3(化合物5a)是一种穿心莲内酯衍生物,是一种有效的ZIKV NS5甲基转移酶(MTase)抑制剂,IC50值为18.34μM。ZIKV-IN-3抑制ZIKV复制和感染。ZIKV-IN-3可用于寨卡病毒(ZIKV)的研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 表观遗传学 >> DNA甲基转移酶
• 靶点实验:

  IC50: 18.34 μM (MTase)[1]

• 体外研究: ZIKV-IN-2(化合物5a；0.08-50μM)抑制ZIKV诱导的斑块形成,EC50值为0.76μM,并对Vero、Huh7和A549细胞具有抗ZIKV作用,EC50分别为0.48、0.37和0.45μM[1]。ZIKV-IN-2(0.08-50μM；48 h)抑制EC50值为0.38μM的ZIKV E蛋白的表达,并抑制ZIKV复制和感染[1]。ZIKV-IN-2(0.08-50μM；96 h)对Vero、Huh7和A549细胞具有低细胞毒性[1]。Vero、Huh7和A549细胞[1]。细胞活力测定[1]细胞株：Vero、Huh7和A549细胞浓度：0.08、0.4、2、10和50μM培养时间：96小时结果：CC50>200μM对所有三种细胞株均表现出低细胞毒性。Western Blot分析[1]细胞株：Vero细胞浓度：0.08、0.4、2、10和50μM培养时间：48小时结果：以剂量依赖性方式抑制ZIVV E蛋白的表达。
• 参考文献:

  [1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710.

ZIKV-IN-3物理化学性质

• 分子式: C₃₉H₄₁NO₄
• 分子量: 587.75

ZIKV-IN-3靶点实验

查看更多实验

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as late RNA synthesis... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353413

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as late viral life cy... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353414

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as late viral life cy... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353411

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as late viral life cy... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353412

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as viral RNA reductio... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353409

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as late entry stage t... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353410

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as inhibition of vira... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353407

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as viral infection at... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353408

实验名称：Inhibition of ZIK virus NS2B-NS3 protease 来源：ChEMBL 靶标：Nonstructural protein 3 External Id：CHEMBL5353405

实验名称：Antiviral activity against ZIKV infected in Vero cells assessed as virucidal effect a... 来源：ChEMBL 靶标：Zika virus External Id：CHEMBL5353406

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