Histone Acetyltransferase抑制剂

• 常用名: Histone Acetyltransferase抑制剂
• 英文名: Remodelin
• CAS号: 949912-58-7
• 分子量: 282.363
• 密度: 1.3±0.1 g/cm3
• 沸点: 498.9±47.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄N₄S
• 熔点: N/A
• 闪点: 255.5±29.3 °C

Histone Acetyltransferase抑制剂用途

Remodelin是乙酰基转移酶NAT10的新型强效选择性抑制剂。

Histone Acetyltransferase抑制剂名称

• 中文名: Histone Acetyltransferase抑制剂
• 英文名: Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]

Histone Acetyltransferase抑制剂生物活性

• 描述: Remodelin是乙酰基转移酶NAT10的新型强效选择性抑制剂。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白乙酰转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32.

Histone Acetyltransferase抑制剂物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 498.9±47.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄N₄S
• 分子量: 282.363
• 闪点: 255.5±29.3 °C
• 精确质量: 282.093903
• PSA: 89.31000
• LogP: 2.16
• InChIKey: XAEJIFARBQJLML-UHFFFAOYSA-N
• SMILES: N#Cc1ccc(-c2csc(NN=C3CCCC3)n2)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.702
• 储存条件: 2-8℃

Histone Acetyltransferase抑制剂靶点实验

查看更多实验

实验名称：Stability of the compound in DMSO-d6 solution assessed as discoloration to dark brown... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739650

实验名称：Stability of the compound in DMSO-d6 solution assessed as drug degradation measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739651

实验名称：Antifungal activity against Candida albicans after 24 hrs by broth microdilution meth... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL907536

实验名称：Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed a... 来源：ChEMBL 靶标：RNA cytidine acetyltransferase External Id：CHEMBL4739648

实验名称：Antifungal activity against Candida glabrata after 24 hrs by broth microdilution meth... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL907537

实验名称：Stability of the light-protected compound in aqueous buffer measured for 7 days 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739649

实验名称：Antifungal activity against Candida tropicalis after 24 hrs by broth microdilution me... 来源：ChEMBL 靶标：Candida tropicalis External Id：CHEMBL907538

实验名称：Redox activity of the compound assessed as H2O2 production at 250 uM in presence of D... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739654

实验名称：Aggregation property of the compound assessed as detergent sensitive inhibition of be... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739655

实验名称：Thiol reactivity with CoA at 1 to 50 uM measured after 30 mins by DACM thiol consumpt... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4739652

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Histone Acetyltransferase抑制剂英文别名

• 4-[2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl]benzonitrile
• 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
• Remodelin