PC190723

• 常用名: PC190723
• 英文名: PC190723
• CAS号: 951120-33-5
• 分子量: 355.75
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₈ClF₂N₃O₂S
• 熔点: N/A
• 闪点: N/A

PC190723用途

PC190723(化合物2)是细菌细胞分裂蛋白FtsZ的抑制剂,IC50为55纳克/毫升。FtsZ-IN-3具有抗葡萄球菌活性,MSSA和MRSA的MIC值为1微克/毫升【1】。

PC190723名称

• 英文名: 3-[(6-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide

PC190723生物活性

• 描述: PC190723(化合物2)是细菌细胞分裂蛋白FtsZ的抑制剂,IC50为55纳克/毫升。FtsZ-IN-3具有抗葡萄球菌活性,MSSA和MRSA的MIC值为1微克/毫升【1】。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 55 ng/ml (FtsZ)[1]

• 参考文献:

  [1]. Buroni S, et al. The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem. 2020 Mar 15;190:112132.

PC190723物理化学性质

• 分子式: C₁₄H₈ClF₂N₃O₂S
• 分子量: 355.75
• 精确质量: 354.99900
• PSA: 106.34000
• LogP: 4.00110
• InChIKey: INYJNSBDHOVLAH-UHFFFAOYSA-N
• SMILES: NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F

PC190723靶点实验

查看更多实验

实验名称：Antibacterial activity against Escherichia coli 25922 assessed as inhibition of bacte... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5104862

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA 41 ass... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5104863

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA 44 ass... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5104864

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5104865

实验名称：Antibacterial activity against Bacillus subtilis 168 assessed as inhibition of bacter... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL5104860

实验名称：Antibacterial activity against Staphylococcus aureus 29213 assessed as inhibition of ... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5104861

实验名称：Bactericidal activity against Staphylococcus aureus ATCC 25923 assessed as 3 log redu... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4390200

实验名称：Antibacterial activity against Bacillus subtilis by broth microdilution method 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL1013357

实验名称：Bactericidal activity against Staphylococcus aureus ATCC 43300 assessed as 3 log redu... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4390201

实验名称：Antibacterial activity against Staphylococcus aureus by broth microdilution method 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1013358

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PC190723英文别名

• 9pc