3'-[5-(1-羟基-1-甲基乙基)-1H-苯并咪唑-1-基]-[1,1'-联苯]-2-甲腈

• 常用名: 3'-[5-(1-羟基-1-甲基乙基)-1H-苯并咪唑-1-基]-[1,1'-联苯]-2-甲腈
• 英文名: NS-11394
• CAS号: 951650-22-9
• 分子量: 353.417
• 密度: 1.2±0.1 g/cm3
• 沸点: 623.7±65.0 °C at 760 mmHg
• 分子式: C₂₃H₁₉N₃O
• 熔点: N/A
• 闪点: 331.0±34.3 °C

用途

NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。

名称

• 中文名: 3'-[5-(1-羟基-1-甲基乙基)-1H-苯并咪唑-1-基]-[1,1'-联苯]-2-甲腈
• 英文名: 2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile

生物活性

• 描述: NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Munro G, et al. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models

  [2]. Mirza NR, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 623.7±65.0 °C at 760 mmHg
• 分子式: C₂₃H₁₉N₃O
• 分子量: 353.417
• 闪点: 331.0±34.3 °C
• 精确质量: 353.152802
• PSA: 61.84000
• LogP: 4.16
• InChIKey: HLKYSQGBIIIQJN-UHFFFAOYSA-N
• SMILES: CC(C)(O)c1ccc2c(c1)ncn2-c1cccc(-c2ccccc2C#N)c1
• 外观性状: white solid
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.637
• 储存条件: -20℃

靶点实验

查看更多实验

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实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

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英文别名

• NS-11394
• 3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile
• 3'-[5-(2-Hydroxy-2-propanyl)-1H-benzimidazol-1-yl]-2-biphenylcarbonitrile
• NS11394