Silvestrol糖苷配基

• 常用名: Silvestrol糖苷配基
• 英文名: Silvestrol aglycone
• CAS号: 960365-65-5
• 分子量: 478.49100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₆O₈
• 熔点: N/A
• 闪点: N/A

Silvestrol糖苷配基名称

• 中文名: Silvestrol糖苷配基
• 英文名: methyl (1R,2R,3S,3aR,8bS)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate

Silvestrol糖苷配基生物活性

• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Kim S, et al. Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7. Anticancer Res. 2007 Jul-Aug;27(4

  [2]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Silvestrol糖苷配基物理化学性质

• 分子式: C₂₇H₂₆O₈
• 分子量: 478.49100
• 精确质量: 478.16300
• PSA: 114.68000
• LogP: 2.83240
• InChIKey: HYLOONIBWUNKDH-PXIJUOARSA-N
• SMILES: COC(=O)C1C(O)C2(O)c3c(OC)cc(O)cc3OC2(c2ccc(OC)cc2)C1c1ccccc1
• 储存条件: 2-8℃

Silvestrol糖苷配基靶点实验

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实验名称：Selectivity index, ratio of EC50 for eIF4FA in human MDA-MB-231 cells transfected wit... 来源：ChEMBL 靶标：Eukaryotic initiation factor 4A-I External Id：CHEMBL2176056

实验名称：Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-lucife... 来源：ChEMBL 靶标：Eukaryotic initiation factor 4A-I External Id：CHEMBL2176057

实验名称：Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2176055

实验名称：Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-lucifer... 来源：ChEMBL 靶标：Eukaryotic initiation factor 4A-I External Id：CHEMBL2176058

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Silvestrol糖苷配基英文别名

• CS-0542
• Silvestrol aglycone