利马扎封

• 常用名: 利马扎封
• 英文名: Rilmazafone
• CAS号: 99593-25-6
• 分子量: 475.33
• 密度: 1.45g/cm3
• 沸点: N/A
• 分子式: C₂₁H₂₀Cl₂N₆O₃
• 熔点: N/A
• 闪点: N/A

利马扎封用途

Rilmazafone 是一种苯二氮卓类 ω 配体,具有镇静和催眠作用。

利马扎封名称

• 中文名: 利马扎封
• 英文名: 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide
• 中文别名: 5-[[(氨基乙酰基)氨基]甲基]-1-[4-氯-2-(2-氯苯甲酰基)苯基]-N,N-二甲基-1H.1,2,4-三唑-3-甲酰胺

利马扎封生物活性

• 描述: Rilmazafone 是一种苯二氮卓类 ω 配体,具有镇静和催眠作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 参考文献:

  [1]. Yasui M, et al. [Pharmacological profiles of benzodiazepinergic hypnotics and correlations with receptor subtypes]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2005 Jun;25(3):143-51.

利马扎封物理化学性质

• 密度: 1.45g/cm3
• 分子式: C₂₁H₂₀Cl₂N₆O₃
• 分子量: 475.33
• 精确质量: 474.09700
• PSA: 123.21000
• LogP: 3.17300
• 折射率: 1.671

利马扎封靶点实验

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实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

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利马扎封英文别名

• 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-(glycylamino-methyl)-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide
• rilmazafone
• 1-[4-bromo-3-methylphenyl]-1H-pyrrole-2,5-dione
• 2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone