A facile synthesis of melatonergic antidepressant agomelatine

B Kandagatla, VVNKV Prasada, GM Reddy, SC Rao…

Index: Kandagatla, Bhaskar; Raju, Vetukuri Venkata Naga Kali Vara Prasada; Reddy, Ganta Madhusudhan; Rao, Sirigiri Chandrakanth; Iqbal, Javed; Bandichhor, Rakeshwar; Oruganti, Srinivas Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7125 - 7127

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Citation Number: 5

Abstract

Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β- nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.