Open-chain nitrogen compounds. Part V. Hydroxymethyltriazenes: synthesis of some new alkyl homologues of the anti-tumour 3-methyl-3-hydroxymethyltriazenes and …

CM Hemens, HW Manning, K Vaughan…

Index: Hemens, Chantal M.; Manning, Hartford W.; Vaughan, Keith; LaFrance, Ronald; Tang, York Canadian Journal of Chemistry, 1984 , vol. 62, p. 741 - 748

Full Text: HTML

Citation Number: 29

Abstract

The synthesis of some new 1-aryl-3-alkyl-3-hydroxymethyltriazenes is described. The method of coupling a diazonium salt with an alkylamine/formaldehyde mixture has been extended to (a) some diazonium ions with para substituents other than-M groups,(b) those with substituents in the ortho position, and (c) to homologous alkylamines (eg ethylamine, propylamine, etc.). Hydroxymethyltriazenes can also be prepared by the reaction of a 1- ...