Journal of Heterocyclic Chemistry

Studies on pyrazines. 7. The synthesis of 5??chloropyrazinecarboxylic acid

N Sato, S Arai

Index: Sato, Nobuhiro; Arai, Shinji Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 407 - 408

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Citation Number: 12

Abstract

Abstract The titled carboxylic acid (1) was prepared by condensation of 2-furylglyoxal with aminoacetamide followed by chlorination of the resulting 2-hydroxy-5-(2′-furyl) pyrazine (2) and permanganate oxidation. The acid was further converted into methyl ester and 5- hydroxypyrazinecarboxylic acid.