Enzymatic removal of carboxyl protecting groups. III. Fast removal of allyl and chloroethyl esters by Bacillus subtilis esterase (BS2)

…, E Barbayianni, V Constantinou-Kokotou…

Index: Barbayianni, Efrosini; Fotakopoulou, Irene; Schmidt, Marlen; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8730 - 8733

Full Text: HTML

Citation Number: 15

Abstract

An esterase from Bacillus subtilis (BS2) allows the fast and selective removal of allyl, 2- chloroethyl, and 2, 2, 2-chloroethyl esters under mild conditions in high yields. In addition, BS2 easily hydrolyzes phenacyl esters, while the hydrolysis of sterically hindered diphenylmethyl esters is slow, requiring longer reaction time and higher enzyme/substrate ratio.

~18%

~95%

~61%

~29%

~91%

~98%

Design, synthesis, and binding studies of bidentate Zn-chela...

[More, Swati S.; Vince, Robert Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3793 - 3797]

Synthesis of enantiomerically pure β-and γ-amino acids from ...

[El Marini; Roumestant; Viallefont; Razafindramboa; Bonato; Follet Synthesis, 1992 , # 11 p. 1104 - 1108]

Utility of tetrathiomolybdate and tetraselenotungstate: effi...

[Bhat, Ramakrishna G.; Porhiel, Emmanuel; Saravanan, Vadivelu; Chandrasekaran, Srinivasan Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5251 - 5253]

SYNTHESE DE L'ACIDE 3??(3, 6??DIOXOPIPERAZIN??2??YL) PROPANO...

[Jerumanis, Stanislas; Lefebvre, Jean Bulletin des Societes Chimiques Belges, 1994 , vol. 103, # 3 p. 127 - 130]

From Animated Portmanteau to the Risus Purus

[Anderson; Barton; Hardy; Kenner; Preston; Sheppard Journal of the Chemical Society. Perkin transactions 1, 1967 , vol. 1, p. 108 - 113]