N-Cbz-L-Glutamic acid 5-tert-butyl ester

Modify Date: 2025-08-26 17:57:00

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure
N-Cbz-L-Glutamic acid 5-tert-butyl ester structure
 Common Name N-Cbz-L-Glutamic acid 5-tert-butyl ester
CAS Number 3886-08-6 Molecular Weight 337.368
Density 1.2±0.1 g/cm3 Boiling Point 522.6±50.0 °C at 760 mmHg
Molecular Formula C17H23NO6 Melting Point 83-87ºC
MSDS Chinese USA Flash Point 269.9±30.1 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of N-Cbz-L-Glutamic acid 5-tert-butyl ester


Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, drug, compounds synthesis[1].

 Names

Name Z-Glu(OtBu)-OH
Synonym More Synonyms

 N-Cbz-L-Glutamic acid 5-tert-butyl ester Biological Activity

Description Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, drug, compounds synthesis[1].
Related Catalog
References

[1]. Shaomeng Wang, et al. Small molecule stat protein degraders. WO2021195481A1 (compound A)

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 522.6±50.0 °C at 760 mmHg
Melting Point 83-87ºC
Molecular Formula C17H23NO6
Molecular Weight 337.368
Flash Point 269.9±30.1 °C
Exact Mass 337.152527
PSA 101.93000
LogP 3.43
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.524

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H317-H319-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38-43
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924299090

 Synthetic Route

Z-L-glutamic acid γ-tert·butyl α-benzyl ester structure

Z-L-glutamic ac...

CAS#:3967-18-8

~61%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Barbayianni, Efrosini; Fotakopoulou, Irene; Schmidt, Marlen; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8730 - 8733
4(S)-(2-tert-butoxycarbonylethyl)-5-oxo-oxazolidine 3-carboxylic acid benzyl ester structure

4(S)-(2-tert-bu...

CAS#:23632-68-0

~83%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Chevallet, Pierre; Garrouste, Patrick; Malawska, Barbara; Martinez, Jean Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7409 - 7412
(S)-1-allyl 5-tert-butyl 2-(((benzyloxy)carbonyl)amino)pentanedioate structure

(S)-1-allyl 5-t...

CAS#:365217-97-6

~88%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Fotakopoulou, Irene; Barbayianni, Efrosini; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 782 - 786
(S)-3-BENZYLOXYCARBONYL-5-OXO-4-OXAZOLIDINEPROPANOIC ACID structure

(S)-3-BENZYLOXY...

CAS#:23632-67-9

~%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Tetrahedron Letters, , vol. 34, # 46 p. 7409 - 7412
Z-Glu-OH structure

Z-Glu-OH

CAS#:1155-62-0

~%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Tetrahedron Letters, , vol. 30, # 49 p. 6859 - 6860
Z-Glu(OtBu)-OMe structure

Z-Glu(OtBu)-OMe

CAS#:56877-41-9

~%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Justus Liebigs Annalen der Chemie, , vol. 673, p. 196 - 207
N/A structure

N/A

CAS#:96762-62-8

~%

N-Cbz-L-Glutamic acid 5-tert-butyl ester Structure

N-Cbz-L-Glutami...

CAS#:3886-08-6

Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 941 - 953

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

(2S)-2-{[(Benzyloxy)carbonyl]amino}-5-tert-butoxy-5-oxopentanoic acid (non-preferred name)
5-tert-butyl ester
MFCD00038274
EINECS 223-421-3
N-Carbobenzoxy-L-glutamic Acid 5-tert-Butyl Ester
(S)-2-(((Benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
N-Benzyloxycarbonyl-L-glutamic acid gamma-tert-butyl ester
N-Cbz-L-Glutamic acid 5-tert-butyl ester
5-tert-Butyl N-Cbz-L-glutamate
(2S)-2-{[(Benzyloxy)carbonyl]amino}-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoate
Cbz-L-glutamic acid 5-tert-butyl ester
(2S)-2-{[(Benzyloxy)carbonyl]amino}-5-tert-butoxy-5-oxopentanoate
5-tert-Butyl N-Carbobenzoxy-L-glutamate
5-tert-Butyl N-((phenylmethoxy)carbonyl)-L-glutamate
L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester, ion(1-)
(2S)-2-{[(Benzyloxy)carbonyl]amino}-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid
L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester
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