A practical non-cryogenic process for the selective functionalization of bromoaryls

…, H Hirt, W Marterer, F Schaefer, M Seeger-Weibel

Index: Gallou, Fabrice; Haenggi, Ruedi; Hirt, Hans; Marterer, Wolfgang; Schaefer, Frank; Seeger-Weibel, Manuela Tetrahedron Letters, 2008 , vol. 49, # 34 p. 5024 - 5027

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Citation Number: 13

Abstract

A selective and practical bromine–metal exchange process under non-cryogenic conditions was developed by a simple modification of an existing protocol. By directly adding an alkyl lithium RLi reagent to a solution of a bromoaryl substrate ArBr and an alkylmagnesium reagent RMgX, a lithium triarylmagnesiate Ar3MgLi complex formed that allowed for various types of functionalization and more elaborate cross-coupling reactions. The simplicity and ...